Kaplan-Meier analysis of overall survival and leukemia-free survival of patients with MDS with a deletion 5q as a chromosomal abnormality. Patients are subdivided into 2 groups according to the molecular taxonomy of MDS illustrated in supplemental Figure 2: the TP53-complex group (defined by the presence of TP53 multihit state and/or CK) or the del(5q) group (defined by the presence of del(5q) as the sole cytogenetic abnormality or with 1 additional abnormality excluding −7/7q, and by the absence of TP53 multihit state). Patients belonging to the TP53-complex group had significantly worse overall survival and higher risk of leukemic transformation, consistent with a substantially different disease biology. These observations substantiate the current diagnostic criteria for MDS-del(5q), which exclude the presence of TP53 multihit state and CK.6,7P values are from the log-rank test.
Figure 2.

Kaplan-Meier analysis of overall survival and leukemia-free survival of patients with MDS with a deletion 5q as a chromosomal abnormality. Patients are subdivided into 2 groups according to the molecular taxonomy of MDS illustrated in supplemental Figure 2: the TP53-complex group (defined by the presence of TP53 multihit state and/or CK) or the del(5q) group (defined by the presence of del(5q) as the sole cytogenetic abnormality or with 1 additional abnormality excluding −7/7q, and by the absence of TP53 multihit state). Patients belonging to the TP53-complex group had significantly worse overall survival and higher risk of leukemic transformation, consistent with a substantially different disease biology. These observations substantiate the current diagnostic criteria for MDS-del(5q), which exclude the presence of TP53 multihit state and CK.6,7 P values are from the log-rank test.

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