Interstitial deletion of the long arm of 1 chromosome 5 and molecular pathogenesis of the MDS-del(5q). (A) The karyogram (R-banding) of a patient with MDS-del(5q): the red arrow indicates the chromosome 5 with an interstitial deletion of the q arm involving bands q31 to q34. (B) The role of haploinsufficiency of multiple genes, located in the common deletion region 5q32-5q33, in the pathophysiology of MDS-del(5q). The karyogram is from the UZ Leuven (Belgium), the institution in which Herman Van den Berghe worked for many years. The microphotographs of the peripheral blood and bone marrow are from the Division of Hematology, Fondazione IRCCS Policlinico San Matteo and University of Pavia (Italy).
Figure 1.

Interstitial deletion of the long arm of 1 chromosome 5 and molecular pathogenesis of the MDS-del(5q). (A) The karyogram (R-banding) of a patient with MDS-del(5q): the red arrow indicates the chromosome 5 with an interstitial deletion of the q arm involving bands q31 to q34. (B) The role of haploinsufficiency of multiple genes, located in the common deletion region 5q32-5q33, in the pathophysiology of MDS-del(5q). The karyogram is from the UZ Leuven (Belgium), the institution in which Herman Van den Berghe worked for many years. The microphotographs of the peripheral blood and bone marrow are from the Division of Hematology, Fondazione IRCCS Policlinico San Matteo and University of Pavia (Italy).

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