Figure 1. Resistance, response, and MRD.... | American Society of Hematology

Figure 1.

$Resistance, response, and MRD. The figure on the left shows the 3 paths of cancers—refractory to therapy, relapse after response, and remission. The red horizonal line reflects clinical complete remission, thus any disease burden below the line that is detectable is MRD. On the right is the summary of a large meta-analysis of nearly 10 000 AML cases across 61 studies. While there is a large difference in outcome based on MRD status, many patients who are MRD negative relapse and die, while many with MRD do not. Why? Right panel reprinted with permission from Short et al.4$

Resistance, response, and MRD. The figure on the left shows the 3 paths of cancers—refractory to therapy, relapse after response, and remission. The red horizonal line reflects clinical complete remission, thus any disease burden below the line that is detectable is MRD. On the right is the summary of a large meta-analysis of nearly 10 000 AML cases across 61 studies. While there is a large difference in outcome based on MRD status, many patients who are MRD negative relapse and die, while many with MRD do not. Why? Right panel reprinted with permission from Short et al.⁴

This Feature Is Available To Subscribers Only