MYC-R are constrained by the preceding BCL2-R. (A) Diagrams showing the topology of MYC and IGH alleles in a precursor cell harboring a IGH::BCL2 rearrangement, followed by the possible positions of rearrangements and their effects on BCL2 and BCR expression. (B) A Sankey diagram comparing the MiXCR-predicted expressed constant gene vs the MYC partner in HGBCL-DH-BCL2 tumors with MYC::IGH rearrangements. The figure legend gives the order of all constant genes and enhancer regions as they appear in the genome. (C) A custom FISH assay designed to identify MYC-R involving the der(14)t(14;18) chromosome, with representative examples of FISH patterns identified. The white arrow indicates the fusion observed in tumors with der(8)t(8;14)t(14;18). (D) The frequency of surface Ig expression determined by flow cytometry, compared with FDR-corrected pairwise Fisher exact tests. RR, regulatory region; ∗P < .05; ∗∗P < .01.
Figure 6.

MYC-R are constrained by the preceding BCL2-R. (A) Diagrams showing the topology of MYC and IGH alleles in a precursor cell harboring a IGH::BCL2 rearrangement, followed by the possible positions of rearrangements and their effects on BCL2 and BCR expression. (B) A Sankey diagram comparing the MiXCR-predicted expressed constant gene vs the MYC partner in HGBCL-DH-BCL2 tumors with MYC::IGH rearrangements. The figure legend gives the order of all constant genes and enhancer regions as they appear in the genome. (C) A custom FISH assay designed to identify MYC-R involving the der(14)t(14;18) chromosome, with representative examples of FISH patterns identified. The white arrow indicates the fusion observed in tumors with der(8)t(8;14)t(14;18). (D) The frequency of surface Ig expression determined by flow cytometry, compared with FDR-corrected pairwise Fisher exact tests. RR, regulatory region; ∗P < .05; ∗∗P < .01.

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