Figure 6.
CPX-351 promotes the abundance of eubiotic microbial pathways. (A) PCoA of predicated functions and (B) SongBird differential analysis of relevant KEGG pathways abundance with corresponding log-ratio rankings visualized with Qurro in mice treated IV as indicated. The CPX-351/“7 + 3” log-ratios of differential modules were selected to generate a box-whisker plot.18 (C) Box-and-whisker plots of relevant metabolic functions by PICRUSt2 analysis. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; and ∗∗∗∗P < .0001; treated vs untreated (None) mice and CPX-351 vs “7 + 3” treatment. One-way ANOVA, Tukey multiple comparison test. Kruskal-Wallis test on all and pairwise samples.
