Immune compartment transcriptional analysis in aGVHD of colon. (A) Two clusters visualized in this unsupervised heat map, IC1 and IC2. Rows represent genes, and each column is an AOI. (B-C) A preponderance of AOIs from LG pathology areas and SS patients in IC2. P value calculated by Fisher exact test. ∗∗∗P = .0007; ∗∗∗∗P < .0001. (D) Hallmark gene set enrichment for IC2 genes with interferon gamma (IFN-γ) response. (E-F) Gene Ontology enrichment for the genes upregulated in IC1 shows involvement of multifaceted DNA-binding pathways principally directed toward cell cycle regulation. (G) Volcano plot of differentially expressed genes between IC1 and IC2. FDR, false discovery rate; RNA Pol II transcrpn. regul. seq. sp. DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding.
Figure 2.

Immune compartment transcriptional analysis in aGVHD of colon. (A) Two clusters visualized in this unsupervised heat map, IC1 and IC2. Rows represent genes, and each column is an AOI. (B-C) A preponderance of AOIs from LG pathology areas and SS patients in IC2. P value calculated by Fisher exact test. ∗∗∗P = .0007; ∗∗∗∗P < .0001. (D) Hallmark gene set enrichment for IC2 genes with interferon gamma (IFN-γ) response. (E-F) Gene Ontology enrichment for the genes upregulated in IC1 shows involvement of multifaceted DNA-binding pathways principally directed toward cell cycle regulation. (G) Volcano plot of differentially expressed genes between IC1 and IC2. FDR, false discovery rate; RNA Pol II transcrpn. regul. seq. sp. DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding.

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