Overview of the samples studied according to omics assays. Frozen peripheral mononuclear blood cells, plasma and cell pellets from patients included in the double-blinded ALLOZITHRO study were retrieved from the national CRYOSTEM biobank. All samples were collected after allogeneic hematopoietic stem cell transplantation, either at the time of acute graft vs host disease or at the nearest visit by day 100. Patients’ characteristics and outcomes are depicted in supplemental Table 1 and supplemental Figure 2.