Figure 1.
TCF3 germline variants in patients with pediatric B-ALL identified by targeted sequencing. (A) CONSORT diagram of COG and St. Jude patients included in this study. (B) Protein domain plot of TCF3 E12 isoform (NM_003200): Activation Domain (AD) 1 to 3 and b-HLH domain. The upper panel shows rare deleterious TCF3 E12 germline variants in patients with B-ALL, and the lower panel shows TCF3 E12 variants in the gnomAD control participants. Each dot represents 1 case.

TCF3 germline variants in patients with pediatric B-ALL identified by targeted sequencing. (A) CONSORT diagram of COG and St. Jude patients included in this study. (B) Protein domain plot of TCF3 E12 isoform (NM_003200): Activation Domain (AD) 1 to 3 and b-HLH domain. The upper panel shows rare deleterious TCF3 E12 germline variants in patients with B-ALL, and the lower panel shows TCF3 E12 variants in the gnomAD control participants. Each dot represents 1 case.

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