Prediction of Gα coupling probabilities of GPR34 and its various mutants by the machine-learning program PRECOG (http://precog.russelllab.org).18 A value >0.5 indicates a high probability of G protein–coupling property and is highlighted in red. The proposed effectors/signaling pathway activations downstream of Gα and Gβγ are based on previous literature.12,25–27 WT, wild type.
Figure 4.

Prediction of Gα coupling probabilities of GPR34 and its various mutants by the machine-learning program PRECOG (http://precog.russelllab.org).18  A value >0.5 indicates a high probability of G protein–coupling property and is highlighted in red. The proposed effectors/signaling pathway activations downstream of Gα and Gβγ are based on previous literature.12,25–27 WT, wild type.

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