Stereotype, somatic hypermutation, and V gene use in CLL subtypes. (A) Frequency of stereotyped immunoglobulin genes in each CLL subtype (19 major stereotype subsets were annotated using ARResT/AssignSubsets tool). P value by χ² test. (B) Frequency of specific stereotypes within each subtype of cases. (C) Boxplots showing percentage of identity to germ line of IGHV gene in each CLL subtype. Percentage of cases carrying borderline IGHV identity (97% to 98%) is shown for each subgroup of cases. Note also that none of the IGLV3-21^R110 cases had 100% IGHV percentage of identity. P value by Wilcoxon test comparing i-CLL cases with and without IGLV3-21^R110. (D) IGHV gene use according to CLL subtype. (E) IG(K/L)V gene use according to CLL subtype. IGKV genes from proximal and distal clusters were merged for simplification. Only the IGLV gene is represented for cases expressing κ and λ gene rearrangements. Q values by χ² test with Benjamini-Hochberg correction. Q < 0.1, *Q < 0.05, **Q < 0.001, ***Q < 0.0001.