Antioxidative gene circuitries are upregulated in MRD cells with high-risk CAs. (A) The number of differentially expressed genes between diagnostic and MRD tumor cells of patients with standard- vs high-risk (n = 26 and 14, respectively) CAs. (B) The Hallmarks of Cancer data set was used for Gene Set Enrichment Analysis (GSEA), based on gene expression in diagnostic and MRD tumor cells of patients with standard- and high-risk CAs. The most enriched pathways (nominal P < .1) are represented for each group (top). (C) PFS according to the messenger RNA (mRNA) expression (high or low, if above or below the median expression) of SOD1 and PRDX6 in diagnostic tumor cells of patients with MM with standard- and high-risk CAs enrolled in the PETHEMA/GEM2012MENOS65 study (n = 157). ***P < .001 by 2-sided log-rank test. (D) PFS according to the mRNA expression (high or low if above or below the median expression) of SOD1 and PRDX6 in diagnostic tumor cells of patients with MM with standard- and high-risk CAs who were enrolled in the CoMMpass study (N = 553). *P < .01, by 2-sided log-rank test.