Characteristic features of CD56+ neoplasms with blast morphology.
| Feature . | Blastic NK-cell Lymphoma . | Aggressive NK-cell Leukemia* . | Myeloid/NK-cell Precursor Leukemia . |
|---|---|---|---|
| ++ = >50%; + = 25%-50%; +/- = 5%-25%; - = <5% | |||
| * Tumor cells vary from mature-appearing large granular lymphocytes (LGLs) to cells with a more blastic appearance | |||
| ** note: 13%-41% of AML overall are CD56+ | |||
| † the number of blasts may be small and involvement patchy compared to other leukemias | |||
| Marrow involvement | ++ | ++† | ++** |
| Skin disease | ++ | - | < 10% |
| Lymph node involvement | + | ++ | ++ |
| Hepatosplenomegaly | ∼15% | + | < 10% |
| Epstein-Barr virus | - | +/- | - |
| Cytoplasmic granules | +/- | + | - |
| Feature . | Blastic NK-cell Lymphoma . | Aggressive NK-cell Leukemia* . | Myeloid/NK-cell Precursor Leukemia . |
|---|---|---|---|
| ++ = >50%; + = 25%-50%; +/- = 5%-25%; - = <5% | |||
| * Tumor cells vary from mature-appearing large granular lymphocytes (LGLs) to cells with a more blastic appearance | |||
| ** note: 13%-41% of AML overall are CD56+ | |||
| † the number of blasts may be small and involvement patchy compared to other leukemias | |||
| Marrow involvement | ++ | ++† | ++** |
| Skin disease | ++ | - | < 10% |
| Lymph node involvement | + | ++ | ++ |
| Hepatosplenomegaly | ∼15% | + | < 10% |
| Epstein-Barr virus | - | +/- | - |
| Cytoplasmic granules | +/- | + | - |