Table 1.

Genes involved in V(D)J recombination.

Gene
Properties
Role in V(D)J Recombination
Other Roles
Rag-1   Endonuclease   Initiation   None known  
Rag-2   Endonuclease   Initiation   None known  
DNA-PKcs   Protein kinase   Rejoining coding ends   Switch recombination  
Ku70   DNA end-binding;   Rejoining coding and signal ends   NHEJ pathway; Growth  
Ku80   DNA end-binding; TdT recruitment   Rejoining coding and signal ends   NHEJ pathway; Growth  
XRCC4   Activates DNA ligase   Rejoining coding and signal ends   NHEJ pathway; Brain development  
DNA Ligase IV   End joining   Rejoining coding and signal ends   NHEJ pathway; Brain development  
TdT   Nucleotide addition   Diversifies coding joins   None known  
Gene
Properties
Role in V(D)J Recombination
Other Roles
Rag-1   Endonuclease   Initiation   None known  
Rag-2   Endonuclease   Initiation   None known  
DNA-PKcs   Protein kinase   Rejoining coding ends   Switch recombination  
Ku70   DNA end-binding;   Rejoining coding and signal ends   NHEJ pathway; Growth  
Ku80   DNA end-binding; TdT recruitment   Rejoining coding and signal ends   NHEJ pathway; Growth  
XRCC4   Activates DNA ligase   Rejoining coding and signal ends   NHEJ pathway; Brain development  
DNA Ligase IV   End joining   Rejoining coding and signal ends   NHEJ pathway; Brain development  
TdT   Nucleotide addition   Diversifies coding joins   None known  
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