Table 1. Main features of the AML cases... | American Society of Hematology

Table 1.

Main features of the AML cases used for analysis of gene expression profiles

Patient no.	NPM loc	NPM gene	FAB	FLT3	Karyotype	CD34
Training set
1	NPMc⁺	Mut	M1	ITD	NK	Neg
2	NPMc⁺	Mut	M1	ITD	NK	Neg
3	NPMc⁺	Mut	M1	ITD	NK	Neg
4	NPMc⁺	Mut	M1	ITD	NK	Neg
5	NPMc⁺	Mut	M1	ITD	NK	Neg
6	NPMc⁺	Mut	M1	ITD	NK	Neg
7	NPMc⁺	Mut	M1	WT	NK	Neg
8	NPMc⁺	Mut	M1	WT	NK	Neg
9	NPMc⁺	Mut	M1	WT	NK	Neg
10	NPMc⁺	Mut	M2	ITD	NK	Pos
11	NPMc⁺	Mut	M2	ITD	NK	Neg
12	NPMc⁺	Mut	M2	ITD	NK	Neg
13	NPMc⁺	Mut	M2	ITD	NK	Neg
14	NPMc⁺	Mut	M2	ITD	NK	Neg
15	NPMc⁺	Mut	M2	ITD	NK	Neg
16	NPMc⁺	Mut	M2	WT	NK	Neg
17	NPMc⁺	Mut	M2	WT	NK	Neg
18	NPMc⁺	Mut	M2	WT	NK	Neg
19	NPMc⁺	Mut	M2	WT	NK	Pos
20	NPMc⁺	Mut	M4	ITD	NK	Neg
21	NPMc⁺	Mut	M4	ITD	NK	Neg
22	NPMc⁺	Mut	M4	WT	NK	Neg
23	NPMc⁺	Mut	M4	WT	NK	Neg
24	NPMc⁺	Mut	M5a	WT	NK	Neg
25	NPMc⁺	Mut	M5a	WT	NK	Neg
26	NPMc⁺	Mut	M5a	WT	NK	Neg
27	NPMc⁺	Mut	M5b	D835	NK	Neg
28	NPMc⁺	Mut	M5b	D835	NK	Neg
29	NPMc⁺	Mut	M5b	WT	NK	Neg
30	NPMc^-	WT	M0	ITD	NK	Pos
31	NPMc^-	WT	M0	WT	NK	Pos
32	NPMc^-	WT	M1	WT	NK	Pos
33	NPMc^-	WT	M1	WT	NK	Pos
34	NPMc^-	WT	M1	WT	NK	Pos
35	NPMc^-	WT	M2	WT	NK	Pos
36	NPMc^-	WT	M4	WT	NK	Pos
37	NPMc^-	WT	M4	WT	NK	Pos
38	NPMc^-	WT	M5a	ITD	NK	Neg
39	NPMc^-	WT	M5a	ITD	NK	Neg
Test set
40	NPMc⁺	Mut	M1	ITD	NK	Neg
41	NPMc⁺	Mut	M1	WT	NK	Neg
42	NPMc⁺	Mut	M2	D835	NK	Neg
43	NPMc⁺	Mut	M2	ITD	NK	Pos
44	NPMc⁺	Mut	M2	WT	NK	Neg
45	NPMc⁺	Mut	M2	WT	NK	Neg
46	NPMc⁺	Mut	M4	D835	NK	Neg
47	NPMc⁺	Mut	M4	ITD	NK	Neg
48	NPMc⁺	Mut	M4	ITD	NK	Neg
49	NPMc⁺	Mut	M4	ITD	NK	Neg
50	NPMc⁺	Mut	M4	ITD/D835	NK	ND
51	NPMc⁺	Mut	M4	WT	NK	Neg
52	NPMc⁺	Mut	M5	ITD	NK	Neg
53	NPMc⁺	Mut	M5a	ITD	NK	Neg
54	NPMc⁺	Mut	M5a	ITD	NK	Neg
55	NPMc⁺	Mut	M5a	WT	NK	Neg
56	NPMc⁺	Mut	M5b	ITD	NK	Neg
57	NPMc⁺	Mut	M5b	ITD	NK	Neg
58	NPMc⁺	Mut	M5b	WT	NK	Neg
59	NPMc⁺	Mut	M5b	WT	NK	Neg
60	NPMc⁺	Mut	M5b	WT	NK	Neg
61	NPMc⁺	Mut	M5b	WT	NK	Neg
62	NPMc⁺	Mut	M0	WT	del(11)	Pos
63	NPMc⁺	Mut	M1	WT	add(1)	Neg
64	NPMc⁺	Mut	M4	ITD	inv(3)	Neg
65	NPMc⁺	Mut	M4	WT	tri(8)	Pos
66	NPMc⁺	Mut	M5b	ITD	del(9)	Neg
67	NPMc⁺	Mut	M5b	ITD/D835	tri(8)	Neg
68	NPMc⁺	Mut	M0	WT	NK	Pos
69	NPMc^-	WT	M1	ITD	NK	Neg
70	NPMc^-	WT	M1	WT	NK	Pos
71	NPMc^-	WT	M2	ITD	NK	Pos
72	NPMc^-	WT	M2	WT	NK	Pos
73	NPMc^-	WT	M2	WT	NK	Pos
74	NPMc^-	WT	M4	ITD	NK	Pos
75	NPMc^-	WT	M4	ITD	NK	Pos
76	NPMc^-	WT	M4	ITD	NK	Pos
77	NPMc^-	WT	M4	WT	NK	Pos
78	NPMc^-	WT	M4e	WT	NK	Pos

Patient no.	NPM loc	NPM gene	FAB	FLT3	Karyotype	CD34
Training set
1	NPMc⁺	Mut	M1	ITD	NK	Neg
2	NPMc⁺	Mut	M1	ITD	NK	Neg
3	NPMc⁺	Mut	M1	ITD	NK	Neg
4	NPMc⁺	Mut	M1	ITD	NK	Neg
5	NPMc⁺	Mut	M1	ITD	NK	Neg
6	NPMc⁺	Mut	M1	ITD	NK	Neg
7	NPMc⁺	Mut	M1	WT	NK	Neg
8	NPMc⁺	Mut	M1	WT	NK	Neg
9	NPMc⁺	Mut	M1	WT	NK	Neg
10	NPMc⁺	Mut	M2	ITD	NK	Pos
11	NPMc⁺	Mut	M2	ITD	NK	Neg
12	NPMc⁺	Mut	M2	ITD	NK	Neg
13	NPMc⁺	Mut	M2	ITD	NK	Neg
14	NPMc⁺	Mut	M2	ITD	NK	Neg
15	NPMc⁺	Mut	M2	ITD	NK	Neg
16	NPMc⁺	Mut	M2	WT	NK	Neg
17	NPMc⁺	Mut	M2	WT	NK	Neg
18	NPMc⁺	Mut	M2	WT	NK	Neg
19	NPMc⁺	Mut	M2	WT	NK	Pos
20	NPMc⁺	Mut	M4	ITD	NK	Neg
21	NPMc⁺	Mut	M4	ITD	NK	Neg
22	NPMc⁺	Mut	M4	WT	NK	Neg
23	NPMc⁺	Mut	M4	WT	NK	Neg
24	NPMc⁺	Mut	M5a	WT	NK	Neg
25	NPMc⁺	Mut	M5a	WT	NK	Neg
26	NPMc⁺	Mut	M5a	WT	NK	Neg
27	NPMc⁺	Mut	M5b	D835	NK	Neg
28	NPMc⁺	Mut	M5b	D835	NK	Neg
29	NPMc⁺	Mut	M5b	WT	NK	Neg
30	NPMc^-	WT	M0	ITD	NK	Pos
31	NPMc^-	WT	M0	WT	NK	Pos
32	NPMc^-	WT	M1	WT	NK	Pos
33	NPMc^-	WT	M1	WT	NK	Pos
34	NPMc^-	WT	M1	WT	NK	Pos
35	NPMc^-	WT	M2	WT	NK	Pos
36	NPMc^-	WT	M4	WT	NK	Pos
37	NPMc^-	WT	M4	WT	NK	Pos
38	NPMc^-	WT	M5a	ITD	NK	Neg
39	NPMc^-	WT	M5a	ITD	NK	Neg
Test set
40	NPMc⁺	Mut	M1	ITD	NK	Neg
41	NPMc⁺	Mut	M1	WT	NK	Neg
42	NPMc⁺	Mut	M2	D835	NK	Neg
43	NPMc⁺	Mut	M2	ITD	NK	Pos
44	NPMc⁺	Mut	M2	WT	NK	Neg
45	NPMc⁺	Mut	M2	WT	NK	Neg
46	NPMc⁺	Mut	M4	D835	NK	Neg
47	NPMc⁺	Mut	M4	ITD	NK	Neg
48	NPMc⁺	Mut	M4	ITD	NK	Neg
49	NPMc⁺	Mut	M4	ITD	NK	Neg
50	NPMc⁺	Mut	M4	ITD/D835	NK	ND
51	NPMc⁺	Mut	M4	WT	NK	Neg
52	NPMc⁺	Mut	M5	ITD	NK	Neg
53	NPMc⁺	Mut	M5a	ITD	NK	Neg
54	NPMc⁺	Mut	M5a	ITD	NK	Neg
55	NPMc⁺	Mut	M5a	WT	NK	Neg
56	NPMc⁺	Mut	M5b	ITD	NK	Neg
57	NPMc⁺	Mut	M5b	ITD	NK	Neg
58	NPMc⁺	Mut	M5b	WT	NK	Neg
59	NPMc⁺	Mut	M5b	WT	NK	Neg
60	NPMc⁺	Mut	M5b	WT	NK	Neg
61	NPMc⁺	Mut	M5b	WT	NK	Neg
62	NPMc⁺	Mut	M0	WT	del(11)	Pos
63	NPMc⁺	Mut	M1	WT	add(1)	Neg
64	NPMc⁺	Mut	M4	ITD	inv(3)	Neg
65	NPMc⁺	Mut	M4	WT	tri(8)	Pos
66	NPMc⁺	Mut	M5b	ITD	del(9)	Neg
67	NPMc⁺	Mut	M5b	ITD/D835	tri(8)	Neg
68	NPMc⁺	Mut	M0	WT	NK	Pos
69	NPMc^-	WT	M1	ITD	NK	Neg
70	NPMc^-	WT	M1	WT	NK	Pos
71	NPMc^-	WT	M2	ITD	NK	Pos
72	NPMc^-	WT	M2	WT	NK	Pos
73	NPMc^-	WT	M2	WT	NK	Pos
74	NPMc^-	WT	M4	ITD	NK	Pos
75	NPMc^-	WT	M4	ITD	NK	Pos
76	NPMc^-	WT	M4	ITD	NK	Pos
77	NPMc^-	WT	M4	WT	NK	Pos
78	NPMc^-	WT	M4e	WT	NK	Pos

NPM loc indicates NPM localization (c⁺, cytoplasmic and nuclear; c^-, nuclear); NPM gene, status of the NPM gene (Mut, mutated; WT, wild type); FAB, M0 to M5 subtypes; FLT3, status of the FLT3 gene (ITD, internal tandem duplication; D835 mutation; WT, wild type); NK, normal karyotype; CD34, immunohistochemical expression of CD34 (Pos, 20% positive blasts; Neg, < 20% positive blasts; ND, no data available).

View Large

This Feature Is Available To Subscribers Only