All adverse events of intensity of at least grade 3 occurring in at least 2 patients
. | Bortezomib dose level, mg/m2 . | . | . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adverse event . | 0.90, N = 6, n (%) . | 1.05, N = 4, n (%) . | 1.20, N = 4, n (%) . | 1.30, N = 16, n (%) . | 1.40, N = 6, n (%) . | 1.50, N = 6, n (%) . | Total, N = 42, n (%) . | ||||||
| Thrombocytopenia | 1 (17) | 3 (75) | 1 (25) | 8 (50) | 3 (50) | 2 (33) | 18 (43) | ||||||
| Lymphopenia | 1 (17) | 3 (75) | 0 | 7 (44) | 2 (33) | 4 (67) | 17 (40) | ||||||
| Neutropenia | 1 (17) | 0 | 1 (25) | 1 (6) | 3 (50) | 1 (17) | 7 (17) | ||||||
| Fatigue | 0 | 1 (25) | 1 (25) | 2 (13) | 1 (17) | 1 (17) | 6 (14) | ||||||
| Pneumonia | 2 (33) | 0 | 0 | 2 (13) | 0 | 2 (33) | 6 (14) | ||||||
| Peripheral neuropathy | 0 | 1 (25) | 0 | 1 (6) | 1 (17) | 2 (33) | 5 (12) | ||||||
| Febrile neutropenia | 1 (17) | 1 (25) | 1 (25) | 1 (6) | 0 | 1 (17) | 4 (10) | ||||||
| Diarrhea | 1 (17) | 0 | 0 | 1 (6) | 0 | 2 (33) | 4 (10) | ||||||
| Bowel obstruction | 0 | 0 | 2 (50) | 1 (6) | 0 | 0 | 3 (7) | ||||||
| Syncope | 1 (17) | 0 | 0 | 0 | 1 (17) | 1 (17) | 3 (7) | ||||||
| Fever | 1 (17) | 0 | 0 | 1 (6) | 0 | 1 (17) | 3 (7) | ||||||
| Anorexia | 0 | 0 | 0 | 2 (13) | 0 | 0 | 2 (5) | ||||||
| Dyspnea | 0 | 0 | 0 | 1 (6) | 0 | 1 (17) | 2 (5) | ||||||
| Hypotension | 1 (17) | 0 | 0 | 1 (6) | 0 | 0 | 2 (5) | ||||||
| Lower gastrointestinal bleeding | 1 (17) | 0 | 0 | 0 | 0 | 1 (17) | 2 (5) | ||||||
| Sinusitis | 1 (17) | 0 | 0 | 1 (6) | 0 | 0 | 2 (5) | ||||||
. | Bortezomib dose level, mg/m2 . | . | . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adverse event . | 0.90, N = 6, n (%) . | 1.05, N = 4, n (%) . | 1.20, N = 4, n (%) . | 1.30, N = 16, n (%) . | 1.40, N = 6, n (%) . | 1.50, N = 6, n (%) . | Total, N = 42, n (%) . | ||||||
| Thrombocytopenia | 1 (17) | 3 (75) | 1 (25) | 8 (50) | 3 (50) | 2 (33) | 18 (43) | ||||||
| Lymphopenia | 1 (17) | 3 (75) | 0 | 7 (44) | 2 (33) | 4 (67) | 17 (40) | ||||||
| Neutropenia | 1 (17) | 0 | 1 (25) | 1 (6) | 3 (50) | 1 (17) | 7 (17) | ||||||
| Fatigue | 0 | 1 (25) | 1 (25) | 2 (13) | 1 (17) | 1 (17) | 6 (14) | ||||||
| Pneumonia | 2 (33) | 0 | 0 | 2 (13) | 0 | 2 (33) | 6 (14) | ||||||
| Peripheral neuropathy | 0 | 1 (25) | 0 | 1 (6) | 1 (17) | 2 (33) | 5 (12) | ||||||
| Febrile neutropenia | 1 (17) | 1 (25) | 1 (25) | 1 (6) | 0 | 1 (17) | 4 (10) | ||||||
| Diarrhea | 1 (17) | 0 | 0 | 1 (6) | 0 | 2 (33) | 4 (10) | ||||||
| Bowel obstruction | 0 | 0 | 2 (50) | 1 (6) | 0 | 0 | 3 (7) | ||||||
| Syncope | 1 (17) | 0 | 0 | 0 | 1 (17) | 1 (17) | 3 (7) | ||||||
| Fever | 1 (17) | 0 | 0 | 1 (6) | 0 | 1 (17) | 3 (7) | ||||||
| Anorexia | 0 | 0 | 0 | 2 (13) | 0 | 0 | 2 (5) | ||||||
| Dyspnea | 0 | 0 | 0 | 1 (6) | 0 | 1 (17) | 2 (5) | ||||||
| Hypotension | 1 (17) | 0 | 0 | 1 (6) | 0 | 0 | 2 (5) | ||||||
| Lower gastrointestinal bleeding | 1 (17) | 0 | 0 | 0 | 0 | 1 (17) | 2 (5) | ||||||
| Sinusitis | 1 (17) | 0 | 0 | 1 (6) | 0 | 0 | 2 (5) | ||||||