Table 3.

PCLP1/podocalyxin expression is reactivated by PHZ-induced hemolytic anemia, and its deficiency induces accumulation of erythrocyte precursors within the hematopoietic compartments

Hematocrit, %
Reticulocyte index,* %
PCLP1+ cells in BM, %
PBS-treated mice    
   Day 2   45 ± 5   2 ± 1   1 ± 1  
PHZ-treated mice    
   Day 2†  32 ± 3   4 ± 3   11 ± 2  
   Day 3   23 ± 4   9 ± 3   24 ± 4  
   Day 6   41 ± 6   67 ± 5   19 ± 3  
   Day 9
 		 52 ± 4
 		 12 ± 2
 		 3 ± 1
 
Hematocrit, %
Reticulocyte index,* %
PCLP1+ cells in BM, %
PBS-treated mice    
   Day 2   45 ± 5   2 ± 1   1 ± 1  
PHZ-treated mice    
   Day 2†  32 ± 3   4 ± 3   11 ± 2  
   Day 3   23 ± 4   9 ± 3   24 ± 4  
   Day 6   41 ± 6   67 ± 5   19 ± 3  
   Day 9
 		 52 ± 4
 		 12 ± 2
 		 3 ± 1
 

The results are expressed as the mean ± SD of 3 separate analyses.

*

Reticulocyte index is expressed as corrected reticulocyte count. Corrected reticulocyte count (%) = reticulocyte count (%) × 45 (normal hematocrit rate)

†

Twenty-four hours after second injection of PHZ

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