Genotype of 128 offspring, at 4 weeks of age, generated by intercrossing TFPI+/–/mTF+/–/hTF+/– mice
. | Genotype . | . | . | . | . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|
| Group . | TFPI . | mTF . | hTF . | Expected, % . | Observed, % . | Observed, no. . | Obs/E, % . | ||
| 1 | +/+ | +/+ | +/o | 6.25 | 10.15 | 13 | 162 | ||
| 2 | +/+ | +/+ | - | 2.08 | 1.56 | 2 | 75 | ||
| 3 | +/+ | +/- | +/o | 12.5 | 10.15 | 13 | 81 | ||
| 4 | +/+ | +/- | - | 4.17 | 0.78 | 1 | 19 | ||
| 5* | +/+ | -/- | +/o | 6.25 | 6.25 | 8 | 100 | ||
| 6 | +/+ | -/- | - | 0 | 0 | 0 | - | ||
| 7 | +/- | +/+ | +/o | 12.5 | 17.96 | 23 | 144 | ||
| 8 | +/- | +/+ | - | 4.17 | 3.13 | 4 | 75 | ||
| 9 | +/- | +/- | +/o | 25 | 28.13 | 36 | 113 | ||
| 10 | +/- | +/- | - | 8.33 | 7.03 | 9 | 84 | ||
| 11* | +/- | -/- | +/o | 12.5 | 10.15 | 13 | 81 | ||
| 12 | +/- | -/- | - | 0 | 0 | 0 | - | ||
| 13 | -/- | +/+ | +/o | 0 | 0 | 0 | - | ||
| 14 | -/- | +/+ | - | 0 | 0 | 0 | - | ||
| 15 | -/- | +/- | +/o | 0 | 0 | 0 | - | ||
| 16 | -/- | +/- | - | 0 | 0 | 0 | - | ||
| 17* | -/- | -/- | +/o | 6.25 | 4.69 | 6 | 75 | ||
| 18 | -/- | -/- | - | 0 | 0 | 0 | - | ||
. | Genotype . | . | . | . | . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|
| Group . | TFPI . | mTF . | hTF . | Expected, % . | Observed, % . | Observed, no. . | Obs/E, % . | ||
| 1 | +/+ | +/+ | +/o | 6.25 | 10.15 | 13 | 162 | ||
| 2 | +/+ | +/+ | - | 2.08 | 1.56 | 2 | 75 | ||
| 3 | +/+ | +/- | +/o | 12.5 | 10.15 | 13 | 81 | ||
| 4 | +/+ | +/- | - | 4.17 | 0.78 | 1 | 19 | ||
| 5* | +/+ | -/- | +/o | 6.25 | 6.25 | 8 | 100 | ||
| 6 | +/+ | -/- | - | 0 | 0 | 0 | - | ||
| 7 | +/- | +/+ | +/o | 12.5 | 17.96 | 23 | 144 | ||
| 8 | +/- | +/+ | - | 4.17 | 3.13 | 4 | 75 | ||
| 9 | +/- | +/- | +/o | 25 | 28.13 | 36 | 113 | ||
| 10 | +/- | +/- | - | 8.33 | 7.03 | 9 | 84 | ||
| 11* | +/- | -/- | +/o | 12.5 | 10.15 | 13 | 81 | ||
| 12 | +/- | -/- | - | 0 | 0 | 0 | - | ||
| 13 | -/- | +/+ | +/o | 0 | 0 | 0 | - | ||
| 14 | -/- | +/+ | - | 0 | 0 | 0 | - | ||
| 15 | -/- | +/- | +/o | 0 | 0 | 0 | - | ||
| 16 | -/- | +/- | - | 0 | 0 | 0 | - | ||
| 17* | -/- | -/- | +/o | 6.25 | 4.69 | 6 | 75 | ||
| 18 | -/- | -/- | - | 0 | 0 | 0 | - | ||
This cross will generate 27 different genotypes. Mice with 1 or 2 copies of the hTF transgene (hTF+/o) were combined, giving 18 different groups. The absence of the transgene is indicated as a minus (-).
Obs indicates observed; E, expected.
Groups 5, 11, and 17 have wild-type, 50%, and no TFPI on a low-TF background, respectively.