Phenotype of CD4+CD56+ leukemic cells at diagnosis
Antigen . | Expression on leukemic cells . | Lineage expression . |
|---|---|---|
| CD1c | No | Subset of myeloid DCs |
| CD2 | Yes | T cells/NK cells |
| CD3 | No | T cells |
| CD4 | Yes | T cells/subset of DCs/leukemic pDCs |
| CD5 | No | T cells |
| CD7 | No | T cells/NK cells |
| CD8 | No | T cells |
| CD11c | No | Subset of myeloid DCs |
| CD13 | No | Myeloid lineage |
| CD14 | No | Monocytes/macrophages |
| CD16 | No | NK cells |
| CD19 | No | B cells |
| CD25 | No | Cytokine receptor |
| CD33 | Yes | Myeloid lineage |
| CD34 | No | Hematopoietic progenitors |
| CD40 | No | Antigen presenting cells |
| CD56 | Yes | NK cells/leukemic pDCs |
| CD57 | No | NK cells |
| CD45RA | Yes | T cells/lymphoid DCs |
| CD45RO | No | T cells |
| CD80 | No | APCs |
| CD83 | No | Mature DCs |
| CD86 | Yes | APCs |
| CD117 | No | Myeloid lineage |
| CD123 | Yes | Lymphoid DCs |
| BDCA-2 | Yes | Lymphoid DCs |
| BDCA-4 | Yes | Lymphoid DCs |
| MPO | No | Myeloid lineage |
Antigen . | Expression on leukemic cells . | Lineage expression . |
|---|---|---|
| CD1c | No | Subset of myeloid DCs |
| CD2 | Yes | T cells/NK cells |
| CD3 | No | T cells |
| CD4 | Yes | T cells/subset of DCs/leukemic pDCs |
| CD5 | No | T cells |
| CD7 | No | T cells/NK cells |
| CD8 | No | T cells |
| CD11c | No | Subset of myeloid DCs |
| CD13 | No | Myeloid lineage |
| CD14 | No | Monocytes/macrophages |
| CD16 | No | NK cells |
| CD19 | No | B cells |
| CD25 | No | Cytokine receptor |
| CD33 | Yes | Myeloid lineage |
| CD34 | No | Hematopoietic progenitors |
| CD40 | No | Antigen presenting cells |
| CD56 | Yes | NK cells/leukemic pDCs |
| CD57 | No | NK cells |
| CD45RA | Yes | T cells/lymphoid DCs |
| CD45RO | No | T cells |
| CD80 | No | APCs |
| CD83 | No | Mature DCs |
| CD86 | Yes | APCs |
| CD117 | No | Myeloid lineage |
| CD123 | Yes | Lymphoid DCs |
| BDCA-2 | Yes | Lymphoid DCs |
| BDCA-4 | Yes | Lymphoid DCs |
| MPO | No | Myeloid lineage |
According to Garand and Robillard,29 leukemic cells are considered to express an antigen when percentage of positive cells is greater than 20%. Leukemic cells were identified on their low expression of CD4525 (Figure 1).