Retroviral integration sites in NUP98-HOXA9/BXH2 leukemia
Gene . | Protein family . | Chromosome location, chromosome No., cM . | Tumor ID . |
|---|---|---|---|
| Transcription | |||
| Meis1 | Homeodomain protein | 11, 18.9 | 14, 15, 16, 53, 128, 134, 151, 478, 497 |
| Sox4 | HMG box protein | 13, 28.4 | 151 |
| C/EBPα | bZIP protein | 7, 25.6 | 53 |
| C/EBPϵ | bZIP protein | 14, 45.8 | 15 |
| Ap-4 | bHLH-ZIP protein | 16, 4.0 | 24 |
| Myb | Myb transcription factor | 10, 21.0 | 134 |
| Tsga | Testis-specific zinc finger | 6, 72.5 | 371 |
| MII3 | Trithorax homologue | 5, 23.8 | 372 |
| Ncoa6ip | Co-repressor complex protein | 4, 3.0 | 115 |
| Signaling | |||
| Fcgr2b | IgG Fc receptor | 1, 172.2 | 24, 39, 151, 371, 372, 377 |
| Fcrl | IgG Fc receptor | 1, 172.2 | 24, 39, 151, 371, 372, 377 |
| Fcrn | IgG Fc receptor | 7, 34.6 | 478 |
| Snx6 | Ser-Thr kinase | 12, 49.1 | 377 |
| Pdgfrb | Receptor tyrosine kinase | 18, 61.3 | 134 |
| Gnas | G protein | 2, 175.5 | 39 |
| Gng3 | G protein | 19, 8.2 | 128 |
| Itpr1 | Inositol-triphosphate receptor | 6, 109.2 | 371 |
| Aps | Substrate for insulin receptor | 5, 134.8 | 115 |
| Agtrp | Angiotensin II receptor, type 1 | 4, 143.4 | 478 |
| Cav2 | Caveolin 2 | 6, 17.1 | 497 |
| Fdft1 | Farnesyl transferase | 14, 54.2 | 56 |
| Rin3 | Ras and Rab interacting protein | 12, 96.5 | 16 |
| Metabolism | |||
| XM138092 | Mitochondrial ATP synthase | 12, 78.9 | 128 |
| Moat-b | ABC transporter 4 | 14, 109.8 | 371 |
| Srd5a2I | Steroid reductase | 5, 75.6 | 39 |
| Kcnd3 | Potassium gate channel | 3, 106.1 | 372 |
| Glu decarboxylase | Glu decarboxylase | 10, 99.6 | 56 |
| Apoptosis | |||
| Bad | Pro-apoptotic molecule | 19, 3.1 | 377 |
| Cytoskeleton/membrane traffic | |||
| Dnalc4 | Dynein motor complex | 15, 80.5 | 39, 128, 134, 151 |
| Dctn3 | Activator of dynein | 4, 41.4 | 377 |
| Transitin | Cytoskeletal protein | 7, 53.5 | 377 |
| Transgelin2 | Muscle contractile protein | 1, 173.8 | 134 |
| Pex16 | Peroxysomal protein | 2, 93.3 | 371 |
| Tuba2 | α-tubulin 2 | 15, 99.8 | 16 |
| Prefoldin subunit 6 | Microtubule-associated chaperonin | 13, 51.3 | 39 |
| Tspan2 | Tetraspanin 2 | 3, 102.8 | 375 |
| Zinc transporter 5 | 15 transmembrane protein | 13, 98.2 | 128 |
| Miscellaneous | |||
| Tgfbi | TGF-β–induced gene | 13, 56.1 | 377 |
| MN1 | Fused to TEL in AML | 5, 109.1 | 372 |
| Osa1 | Chromatin remodeling complex | 4, 131.2 | 151 |
| Rrm1 | Ribonucleotide reductase | 7, 92.2 | 128 |
| Mms2 | Ubiquitin conjugating enzyme | 15, 31.6 | 56 |
| Cyclophilin 18 | Peptidyl-prolyl cis-trans isomerase | 3, 134.8 | 128 |
| Rpl44 | Ribosomal protein L44 | 12, 63.8 | 478 |
| Agrp | Agouti-related | 8, 105.4 | 478 |
| Ptma | Prothymoshin α | 1, 86.9 | 478 |
| Mrvil | Jaw1 homologue | 7, 100.5 | 371 |
| Unknown | |||
| BI526426 (Con1) | Not determined | 13, 48.9 | 39, 115, 377 |
| AI854024 (Con2) | Not determined | 3, 121.7 | 24, 39, 53 |
Gene . | Protein family . | Chromosome location, chromosome No., cM . | Tumor ID . |
|---|---|---|---|
| Transcription | |||
| Meis1 | Homeodomain protein | 11, 18.9 | 14, 15, 16, 53, 128, 134, 151, 478, 497 |
| Sox4 | HMG box protein | 13, 28.4 | 151 |
| C/EBPα | bZIP protein | 7, 25.6 | 53 |
| C/EBPϵ | bZIP protein | 14, 45.8 | 15 |
| Ap-4 | bHLH-ZIP protein | 16, 4.0 | 24 |
| Myb | Myb transcription factor | 10, 21.0 | 134 |
| Tsga | Testis-specific zinc finger | 6, 72.5 | 371 |
| MII3 | Trithorax homologue | 5, 23.8 | 372 |
| Ncoa6ip | Co-repressor complex protein | 4, 3.0 | 115 |
| Signaling | |||
| Fcgr2b | IgG Fc receptor | 1, 172.2 | 24, 39, 151, 371, 372, 377 |
| Fcrl | IgG Fc receptor | 1, 172.2 | 24, 39, 151, 371, 372, 377 |
| Fcrn | IgG Fc receptor | 7, 34.6 | 478 |
| Snx6 | Ser-Thr kinase | 12, 49.1 | 377 |
| Pdgfrb | Receptor tyrosine kinase | 18, 61.3 | 134 |
| Gnas | G protein | 2, 175.5 | 39 |
| Gng3 | G protein | 19, 8.2 | 128 |
| Itpr1 | Inositol-triphosphate receptor | 6, 109.2 | 371 |
| Aps | Substrate for insulin receptor | 5, 134.8 | 115 |
| Agtrp | Angiotensin II receptor, type 1 | 4, 143.4 | 478 |
| Cav2 | Caveolin 2 | 6, 17.1 | 497 |
| Fdft1 | Farnesyl transferase | 14, 54.2 | 56 |
| Rin3 | Ras and Rab interacting protein | 12, 96.5 | 16 |
| Metabolism | |||
| XM138092 | Mitochondrial ATP synthase | 12, 78.9 | 128 |
| Moat-b | ABC transporter 4 | 14, 109.8 | 371 |
| Srd5a2I | Steroid reductase | 5, 75.6 | 39 |
| Kcnd3 | Potassium gate channel | 3, 106.1 | 372 |
| Glu decarboxylase | Glu decarboxylase | 10, 99.6 | 56 |
| Apoptosis | |||
| Bad | Pro-apoptotic molecule | 19, 3.1 | 377 |
| Cytoskeleton/membrane traffic | |||
| Dnalc4 | Dynein motor complex | 15, 80.5 | 39, 128, 134, 151 |
| Dctn3 | Activator of dynein | 4, 41.4 | 377 |
| Transitin | Cytoskeletal protein | 7, 53.5 | 377 |
| Transgelin2 | Muscle contractile protein | 1, 173.8 | 134 |
| Pex16 | Peroxysomal protein | 2, 93.3 | 371 |
| Tuba2 | α-tubulin 2 | 15, 99.8 | 16 |
| Prefoldin subunit 6 | Microtubule-associated chaperonin | 13, 51.3 | 39 |
| Tspan2 | Tetraspanin 2 | 3, 102.8 | 375 |
| Zinc transporter 5 | 15 transmembrane protein | 13, 98.2 | 128 |
| Miscellaneous | |||
| Tgfbi | TGF-β–induced gene | 13, 56.1 | 377 |
| MN1 | Fused to TEL in AML | 5, 109.1 | 372 |
| Osa1 | Chromatin remodeling complex | 4, 131.2 | 151 |
| Rrm1 | Ribonucleotide reductase | 7, 92.2 | 128 |
| Mms2 | Ubiquitin conjugating enzyme | 15, 31.6 | 56 |
| Cyclophilin 18 | Peptidyl-prolyl cis-trans isomerase | 3, 134.8 | 128 |
| Rpl44 | Ribosomal protein L44 | 12, 63.8 | 478 |
| Agrp | Agouti-related | 8, 105.4 | 478 |
| Ptma | Prothymoshin α | 1, 86.9 | 478 |
| Mrvil | Jaw1 homologue | 7, 100.5 | 371 |
| Unknown | |||
| BI526426 (Con1) | Not determined | 13, 48.9 | 39, 115, 377 |
| AI854024 (Con2) | Not determined | 3, 121.7 | 24, 39, 53 |