Selected genes with potential importance in myeloma biology
Gene . | Other names . | Chromosomal location . | Function . | Involvement/role in other cancers . |
|---|---|---|---|---|
| MD-2 | Lymphocyte antigen 96 | 8q13.3 | Immune response, NFκB activation | Immune modulation |
| RING1 | Ring finger protein 1 | 6p21.3 | Transcriptional repressor, polycomb protein complex | Mantle cell lymphoma, acute leukemia |
| PAK-3 | P21 (CDKN1A)-activated kinase-3 | Xq22.3-q23 | Serine threonine kinase activated by CDC42, Rac | Breast |
| RAN | RAS-related nuclear protein | 6p21 | Small GTP-binding protein, translocation of RNA and protein through nuclear complex | Teratocarcinoma |
| RAD51 | Rec A homologue | 15q15.1 | Homologous recombination | Breast, lung, pancrease, CLL |
| DAD1 | Defender against death 1 | 14q11-q12 | Antiapoptotic | Hepatocellular carcinoma |
| TNFR17 | BCMA | 16p13.1 | B-cell maturation | B-cell malignancies |
Gene . | Other names . | Chromosomal location . | Function . | Involvement/role in other cancers . |
|---|---|---|---|---|
| MD-2 | Lymphocyte antigen 96 | 8q13.3 | Immune response, NFκB activation | Immune modulation |
| RING1 | Ring finger protein 1 | 6p21.3 | Transcriptional repressor, polycomb protein complex | Mantle cell lymphoma, acute leukemia |
| PAK-3 | P21 (CDKN1A)-activated kinase-3 | Xq22.3-q23 | Serine threonine kinase activated by CDC42, Rac | Breast |
| RAN | RAS-related nuclear protein | 6p21 | Small GTP-binding protein, translocation of RNA and protein through nuclear complex | Teratocarcinoma |
| RAD51 | Rec A homologue | 15q15.1 | Homologous recombination | Breast, lung, pancrease, CLL |
| DAD1 | Defender against death 1 | 14q11-q12 | Antiapoptotic | Hepatocellular carcinoma |
| TNFR17 | BCMA | 16p13.1 | B-cell maturation | B-cell malignancies |