Genes differentially expressed between MGUS and MM
Gene . | Name . | Accession number . | Fold change . | P . |
|---|---|---|---|---|
| Cell growth and maintenance | ||||
| LILRB1 | Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | AF004230 | −8.26 | .03 |
| DEFA3 | Defensin, α3, neutrophil-specific | L12691 | −2.9 | .04 |
| CTSG | Cathepsin G | M16117 | −2.78 | .03 |
| TNFRSF7 | Tumor necrosis factor receptor superfamily, member 7 | M63928 | −2.58 | .03 |
| GLUL | Glutamate-ammonia ligase (glutamine synthase) | X59834 | −2.47 | .03 |
| MARCKS | Myristoylated alanine-rich protein kinase C substrate | D10522 | −2.41 | .04 |
| TLR1 | Toll-like receptor 1 | AL050262 | −2.09 | .04 |
| S100A8 | S100 calcium binding protein A8 (calgranulin A) | A1126134 | −1.88 | .01 |
| LITAF | Lipopolysaccharide-induced TNF factor | AL120815 | −1.65 | .04 |
| VNN2 | Vanin 2 | D89974 | −1.63 | .04 |
| SLC7A7 | Solute carrier family 7 | AJ130718 | −1.61 | .04 |
| PDE6G | Phosphodiesterase 6G, cGMP-specific, rod, γ | X62025 | 1.32 | .02 |
| MTA1L1 | Metastasis-associated 1-like 1 | AB012922 | 1.37 | .03 |
| UBE2G2 | Ubiquitin-conjugating enzyme E2G 2 | AF032456 | 1.65 | .006 |
| Signal transduction | ||||
| MERTK | c-mer proto-oncogene tyrosine kinase | U08023 | −3.52 | .04 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | M33195 | −2.89 | .01 |
| RNASE6 | Ribonuclease RNase A family k6 | A1142565 | −2.75 | .02 |
| LY96 | Lymphocyte antigen 96 | AB018549 | −2.23 | .04 |
| LASP1 | LIM and SH3 protein 1 | X82456 | −1.91 | .02 |
| ARHGAP1 | Rho GTPase activating protein 1 | U02570 | −1.8 | .03 |
| PFTK1 | PFTAIRE protein kinase 1 | AB020641 | −1.69 | .0009 |
| CAP | Adenylyl cyclase-associated protein | L12168 | −1.67 | .03 |
| DOK1 | Docking protein 1 62 kDa (downstream of tyrosine kinase 1) | U70987 | −1.62 | .05 |
| RPS6KA4 | Ribosomal protein S6 kinase, 90 kDa, polypeptide 4 | AJ010119 | 1.44 | .03 |
| ITGA8 | Integrin α8 | L36531 | 2.14 | .01 |
| Structural proteins | ||||
| PPBP | Pro-platelet basic protein (chemokine [C-X-C motif] ligand 7) | M54995 | −5.54 | .01 |
| ACTN1 | Actinin, α1 | X15804 | −4.83 | .01 |
| MYH9 | Myosin, heavy polypeptide 9, nonmuscle | Z82215 | −2.07 | .02 |
| ADD1 | Adducin 1 (α) | X58141 | −1.92 | .02 |
| VCL | Vinculin | M33308 | −1.83 | .05 |
| SGCE | Sarcoglycan epsilon | AJ000534 | 1.53 | .003 |
| Developmental processes | ||||
| TMSB4X | Thymosin, β4, X chromosome | M17733 | −2.32 | .04 |
| PITX3 | Paired-like homeodomain transcription factor 3 | AF041339 | 1.3 | .003 |
| FAT | FAT tumor-suppressor homolog 1 (Drosophila) | X87241 | 1.55 | .04 |
| MFNG | Manic fringe homolog (Drosphila) | Z93096 | 1.6 | .02 |
| RING1 | Ring finger protein 1 | AL031228 | 2.09 | .01 |
| FRZB | Frizzled-related protein | U91903 | 6.4 | .05 |
| Others | ||||
| NPC2 | Niemann-Pick disease, type C2 | AI525834 | −3.19 | .003 |
| SAT | Spermidine/spermine N1-acetyltransferase | AL050290 | −2.95 | .01 |
| RAGD* | Rag D protein | W27549 | 1.93 | .03 |
| HIST1H2BG | Histone 1, H2bg | AJ223352 | 1.93 | .02 |
Gene . | Name . | Accession number . | Fold change . | P . |
|---|---|---|---|---|
| Cell growth and maintenance | ||||
| LILRB1 | Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | AF004230 | −8.26 | .03 |
| DEFA3 | Defensin, α3, neutrophil-specific | L12691 | −2.9 | .04 |
| CTSG | Cathepsin G | M16117 | −2.78 | .03 |
| TNFRSF7 | Tumor necrosis factor receptor superfamily, member 7 | M63928 | −2.58 | .03 |
| GLUL | Glutamate-ammonia ligase (glutamine synthase) | X59834 | −2.47 | .03 |
| MARCKS | Myristoylated alanine-rich protein kinase C substrate | D10522 | −2.41 | .04 |
| TLR1 | Toll-like receptor 1 | AL050262 | −2.09 | .04 |
| S100A8 | S100 calcium binding protein A8 (calgranulin A) | A1126134 | −1.88 | .01 |
| LITAF | Lipopolysaccharide-induced TNF factor | AL120815 | −1.65 | .04 |
| VNN2 | Vanin 2 | D89974 | −1.63 | .04 |
| SLC7A7 | Solute carrier family 7 | AJ130718 | −1.61 | .04 |
| PDE6G | Phosphodiesterase 6G, cGMP-specific, rod, γ | X62025 | 1.32 | .02 |
| MTA1L1 | Metastasis-associated 1-like 1 | AB012922 | 1.37 | .03 |
| UBE2G2 | Ubiquitin-conjugating enzyme E2G 2 | AF032456 | 1.65 | .006 |
| Signal transduction | ||||
| MERTK | c-mer proto-oncogene tyrosine kinase | U08023 | −3.52 | .04 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | M33195 | −2.89 | .01 |
| RNASE6 | Ribonuclease RNase A family k6 | A1142565 | −2.75 | .02 |
| LY96 | Lymphocyte antigen 96 | AB018549 | −2.23 | .04 |
| LASP1 | LIM and SH3 protein 1 | X82456 | −1.91 | .02 |
| ARHGAP1 | Rho GTPase activating protein 1 | U02570 | −1.8 | .03 |
| PFTK1 | PFTAIRE protein kinase 1 | AB020641 | −1.69 | .0009 |
| CAP | Adenylyl cyclase-associated protein | L12168 | −1.67 | .03 |
| DOK1 | Docking protein 1 62 kDa (downstream of tyrosine kinase 1) | U70987 | −1.62 | .05 |
| RPS6KA4 | Ribosomal protein S6 kinase, 90 kDa, polypeptide 4 | AJ010119 | 1.44 | .03 |
| ITGA8 | Integrin α8 | L36531 | 2.14 | .01 |
| Structural proteins | ||||
| PPBP | Pro-platelet basic protein (chemokine [C-X-C motif] ligand 7) | M54995 | −5.54 | .01 |
| ACTN1 | Actinin, α1 | X15804 | −4.83 | .01 |
| MYH9 | Myosin, heavy polypeptide 9, nonmuscle | Z82215 | −2.07 | .02 |
| ADD1 | Adducin 1 (α) | X58141 | −1.92 | .02 |
| VCL | Vinculin | M33308 | −1.83 | .05 |
| SGCE | Sarcoglycan epsilon | AJ000534 | 1.53 | .003 |
| Developmental processes | ||||
| TMSB4X | Thymosin, β4, X chromosome | M17733 | −2.32 | .04 |
| PITX3 | Paired-like homeodomain transcription factor 3 | AF041339 | 1.3 | .003 |
| FAT | FAT tumor-suppressor homolog 1 (Drosophila) | X87241 | 1.55 | .04 |
| MFNG | Manic fringe homolog (Drosphila) | Z93096 | 1.6 | .02 |
| RING1 | Ring finger protein 1 | AL031228 | 2.09 | .01 |
| FRZB | Frizzled-related protein | U91903 | 6.4 | .05 |
| Others | ||||
| NPC2 | Niemann-Pick disease, type C2 | AI525834 | −3.19 | .003 |
| SAT | Spermidine/spermine N1-acetyltransferase | AL050290 | −2.95 | .01 |
| RAGD* | Rag D protein | W27549 | 1.93 | .03 |
| HIST1H2BG | Histone 1, H2bg | AJ223352 | 1.93 | .02 |
Values in -fold change are expressed using the MGUS group as the baseline.
Not a human gene nomenclature database symbol.