Frequency and severity of adverse events that where possibly, probably, or definitely related to SU5416 administration in patients who received at least one dose (n = 42) and seen in less than 5% of study patients
. | Number of patients experiencing events (%) . | . | . | ||
|---|---|---|---|---|---|
| Adverse event . | Grades 1 + 2 . | Grades 3 + 4 . | Total . | ||
| All events | 31 (74) | 19 (45) | 34 (81) | ||
| Bone/muscoloskeletal pain | 13 (31) | 3 (7) | 13 (31) | ||
| Nausea | 13 (31) | 1 (2) | 13 (31) | ||
| Headache | 11 (26) | 1 (7) | 11 (26) | ||
| Insomnia | 10 (24) | 0 | 10 (24) | ||
| Vomiting | 7 (17) | 0 | 7 (17) | ||
| Fatigue/malaise | 5 (12) | 3 (7) | 5 (12) | ||
| Vertigo | 5 (12) | 0 | 5 (12) | ||
| Abdominal pain | 4 (10) | 0 | 4 (10) | ||
| Diaphoresis | 4 (10) | 0 | 4 (10) | ||
| Chest pain | 3 (7) | 1 (2) | 4 (10) | ||
| Hypokalemia | 3 (7) | 0 | 3 (7) | ||
| Implant infection | 2 (5) | 1 (2) | 3 (7) | ||
| Sepsis | 0 | 3 (7) | 3 (7) | ||
. | Number of patients experiencing events (%) . | . | . | ||
|---|---|---|---|---|---|
| Adverse event . | Grades 1 + 2 . | Grades 3 + 4 . | Total . | ||
| All events | 31 (74) | 19 (45) | 34 (81) | ||
| Bone/muscoloskeletal pain | 13 (31) | 3 (7) | 13 (31) | ||
| Nausea | 13 (31) | 1 (2) | 13 (31) | ||
| Headache | 11 (26) | 1 (7) | 11 (26) | ||
| Insomnia | 10 (24) | 0 | 10 (24) | ||
| Vomiting | 7 (17) | 0 | 7 (17) | ||
| Fatigue/malaise | 5 (12) | 3 (7) | 5 (12) | ||
| Vertigo | 5 (12) | 0 | 5 (12) | ||
| Abdominal pain | 4 (10) | 0 | 4 (10) | ||
| Diaphoresis | 4 (10) | 0 | 4 (10) | ||
| Chest pain | 3 (7) | 1 (2) | 4 (10) | ||
| Hypokalemia | 3 (7) | 0 | 3 (7) | ||
| Implant infection | 2 (5) | 1 (2) | 3 (7) | ||
| Sepsis | 0 | 3 (7) | 3 (7) | ||