Table 1. Potency of metalloproteinase... | American Society of Hematology

Table 1.

Potency of metalloproteinase inhibitors used in the current study for inhibition of recombinant TACE and ADAM10 ectodomain

	IC₅₀, nM^*
Compound	TACE	ADAM10	ADAM10 potency/TACE potency†
GI254023X	541.0	5.3	102.0
GW280264X	8.0	11.5	1.4

	IC₅₀, nM^*
Compound	TACE	ADAM10	ADAM10 potency/TACE potency†
GI254023X	541.0	5.3	102.0
GW280264X	8.0	11.5	1.4

The inhibitor concentration leading to half maximal inhibition (IC₅₀) of recombinant TACE or ADAM10 ectodomain was determined as described in “Materials and methods.”

†

Potency is defined as 1/IC₅₀.

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