Side effects from imatinib mesylate
| Side effect . | No. patients (%) . | ||
|---|---|---|---|
| Grade 1-2 . | Grade 3-4 . | Any grade . | |
| Nausea, vomiting | 35 (47) | 1 (1) | |
| Diarrhea | 14 (19) | ||
| Skin rashes | 17 (23) | ||
| Muscle cramps, bone and joint aches | 23 (31) | 1 (1) | |
| Fluid retention | 27 (36) | 5 (7) | |
| Periorbital | 8 (11) | ||
| Lower extremities | 10 (13) | 1 (1) | |
| Liver dysfunction | 35 (47) | 6 (8) | |
| Other (congestive heart failure, renal) | 2 (3) | 1 (1) | |
| Granulocytopenia < 0.5 × 109/L | 24/48 (50)5-150 | ||
| Thrombocytopenia | |||
| < 50 × 109/L | 15/34 (44)5-150 | ||
| < 10 × 109/L | 5/34 (15)5-150 | ||
| Febrile episodes | 13 (17) | ||
| Unknown origin | 6 (8) | ||
| Bacterial infection | 5 (7) | ||
| Other infection | 2 (3) | ||
| Side effect . | No. patients (%) . | ||
|---|---|---|---|
| Grade 1-2 . | Grade 3-4 . | Any grade . | |
| Nausea, vomiting | 35 (47) | 1 (1) | |
| Diarrhea | 14 (19) | ||
| Skin rashes | 17 (23) | ||
| Muscle cramps, bone and joint aches | 23 (31) | 1 (1) | |
| Fluid retention | 27 (36) | 5 (7) | |
| Periorbital | 8 (11) | ||
| Lower extremities | 10 (13) | 1 (1) | |
| Liver dysfunction | 35 (47) | 6 (8) | |
| Other (congestive heart failure, renal) | 2 (3) | 1 (1) | |
| Granulocytopenia < 0.5 × 109/L | 24/48 (50)5-150 | ||
| Thrombocytopenia | |||
| < 50 × 109/L | 15/34 (44)5-150 | ||
| < 10 × 109/L | 5/34 (15)5-150 | ||
| Febrile episodes | 13 (17) | ||
| Unknown origin | 6 (8) | ||
| Bacterial infection | 5 (7) | ||
| Other infection | 2 (3) | ||
Denominators indicate the numbers of patients showing granulocytes > 109/L or platelets ≥ 100 × 109/L before treatment.