Sequence of Bcl-2, Bcl-x, Mcl-1, and control antisense oligonucleotides
| Target . | Name . | Sequence (5′-3′) . |
|---|---|---|
| Bcl-2 | ISIS 21 939 | ATGCGGAATTGCCCAGGGAC |
| Bcl-2 control | ISIS 23 983 | ATTCGTAATTACCCTGAGAC |
| Bcl-x | ISIS 16 009 | CTACGCTTTCCACGCACAGT |
| Bcl-x control | ISIS 16 967 | CTCCAATGTCCCCTCAAGGT |
| Mcl-1 | ISIS 20 408 | TTGGCTTTGTGTCCTTGGCG |
| Target . | Name . | Sequence (5′-3′) . |
|---|---|---|
| Bcl-2 | ISIS 21 939 | ATGCGGAATTGCCCAGGGAC |
| Bcl-2 control | ISIS 23 983 | ATTCGTAATTACCCTGAGAC |
| Bcl-x | ISIS 16 009 | CTACGCTTTCCACGCACAGT |
| Bcl-x control | ISIS 16 967 | CTCCAATGTCCCCTCAAGGT |
| Mcl-1 | ISIS 20 408 | TTGGCTTTGTGTCCTTGGCG |
The sequence is shown for antisense oligonucleotides targeting Bcl-2, Bcl-x, or Mcl-1 messenger RNA. The 2-O-methoxyethyl-modified nucleotides are represented by boldface letters and the 2-deoxynucleotides by nonboldface letters. Oligonucleotides were further modified by phosphorothioate linkage.