Induced hematopoietic lineage switches
| Cell type of origin . | Resulting cell type . | Type of manipulation . | Reference . |
|---|---|---|---|
| Pre–B lymphoma cell line | Macrophages | 5-azacytidine treatment | 6 |
| Eu-Myc B lymphoma lines | Macrophages | v-raf expr | 7 |
| Pre–B cell lines | Macrophages | v-fms, CSF1-R plus CSF1 | 8 |
| Pre–B lymphoma | Neutrophil granulocytes | Transplantation | 9 |
| Pax-5−/− pre–B cells | Mac/Gr, dendrites, NK cells | Different cytokines | 11 |
| Pax-5−/− pre–B cells | As above, plus T cells | Transplanted into Rag2−/− | 10 |
| Lymphoid prog. (CLPs) | GM-CSF | IL-2 Rα expr, IL-2 | 13 |
| CD19+ B220−cells | Macrophages | Myeloid culture conditions | 14 |
| Pro–T cells | Macrophages | Conditioned medium | 22 |
| Macrophage cell line (70Z/3) | B-lineage cells | E2A, EBF expr | 15 |
| MEP cells | Myeloid cells | Inducible PU.1 expr | 30 |
| MEP cells | Eosinophils | Inducible C/EBP expr | 31,41 |
| Myeloid cell line (HD50M) | Eosinophils | Inducible GATA-1 expr | 32 |
| Myeloid cell line (HD50M) | MEPs; erythrocytes | High GATA-1 expr; ts Ets | 32 |
| Eosinophil cell line (1A1) | MEP cells | FOG-1 expr | 33 |
| Erythroid cell line (MEL) | Macrophagelike cells | Inducible PU.1 expr | 34 |
| Myeloid cell line (416B) | Megakaryocytic cells | GATA-1, GATA-2 expr | 35 |
| Myeloid cell line (FDCW2) | Erythroid cells | GATA-1 expr | 36 |
| Myeloid cell line (M1) | Megakar, erythroid cells | GATA-1 expr | 37 |
| GM precursors | Ery, eosin, basoph cells | Inducible GATA-1 | T. Enver pers comm., September 2001 |
| Cell type of origin . | Resulting cell type . | Type of manipulation . | Reference . |
|---|---|---|---|
| Pre–B lymphoma cell line | Macrophages | 5-azacytidine treatment | 6 |
| Eu-Myc B lymphoma lines | Macrophages | v-raf expr | 7 |
| Pre–B cell lines | Macrophages | v-fms, CSF1-R plus CSF1 | 8 |
| Pre–B lymphoma | Neutrophil granulocytes | Transplantation | 9 |
| Pax-5−/− pre–B cells | Mac/Gr, dendrites, NK cells | Different cytokines | 11 |
| Pax-5−/− pre–B cells | As above, plus T cells | Transplanted into Rag2−/− | 10 |
| Lymphoid prog. (CLPs) | GM-CSF | IL-2 Rα expr, IL-2 | 13 |
| CD19+ B220−cells | Macrophages | Myeloid culture conditions | 14 |
| Pro–T cells | Macrophages | Conditioned medium | 22 |
| Macrophage cell line (70Z/3) | B-lineage cells | E2A, EBF expr | 15 |
| MEP cells | Myeloid cells | Inducible PU.1 expr | 30 |
| MEP cells | Eosinophils | Inducible C/EBP expr | 31,41 |
| Myeloid cell line (HD50M) | Eosinophils | Inducible GATA-1 expr | 32 |
| Myeloid cell line (HD50M) | MEPs; erythrocytes | High GATA-1 expr; ts Ets | 32 |
| Eosinophil cell line (1A1) | MEP cells | FOG-1 expr | 33 |
| Erythroid cell line (MEL) | Macrophagelike cells | Inducible PU.1 expr | 34 |
| Myeloid cell line (416B) | Megakaryocytic cells | GATA-1, GATA-2 expr | 35 |
| Myeloid cell line (FDCW2) | Erythroid cells | GATA-1 expr | 36 |
| Myeloid cell line (M1) | Megakar, erythroid cells | GATA-1 expr | 37 |
| GM precursors | Ery, eosin, basoph cells | Inducible GATA-1 | T. Enver pers comm., September 2001 |
Prog indicates, progenitor; expr, expression; megakary, megakaryocyte; ery, erythrocyte; eosin, eosinophil; basoph, basophil; and pers comm, personal communication.