Toxicity during induction (protocol IA)
| . | E coli–asparaginase no. (%) of patients N = 354 (100%) . | Erwinia-asparaginase no. (%) of patients N = 346 (100%) . |
|---|---|---|
| Allergy (WHO 3-4) | 9 (2.5) | 9 (2.6) |
| Coagulation abnormalities | 107 (30.2) | 41 (11.8) |
| Neurotoxicity (WHO 3-4) | 9 (2.5) | 5 (1.4) |
| Convulsions | 6 (1.7) | 1 (0.3) |
| Pancreatitis | 1 (0.3) | 3 (0.9) |
| Diabetes requiring insulin | 5 (1.4) | 2 (0.6) |
| Liver toxicity (WHO 3-4) | 16 (4.5) | 13 (3.8) |
| Infection (WHO 3-4) | 18 (5.1) | 16 (4.6) |
| Death | 1 (0.3) | 2 (0.6) |
| . | E coli–asparaginase no. (%) of patients N = 354 (100%) . | Erwinia-asparaginase no. (%) of patients N = 346 (100%) . |
|---|---|---|
| Allergy (WHO 3-4) | 9 (2.5) | 9 (2.6) |
| Coagulation abnormalities | 107 (30.2) | 41 (11.8) |
| Neurotoxicity (WHO 3-4) | 9 (2.5) | 5 (1.4) |
| Convulsions | 6 (1.7) | 1 (0.3) |
| Pancreatitis | 1 (0.3) | 3 (0.9) |
| Diabetes requiring insulin | 5 (1.4) | 2 (0.6) |
| Liver toxicity (WHO 3-4) | 16 (4.5) | 13 (3.8) |
| Infection (WHO 3-4) | 18 (5.1) | 16 (4.6) |
| Death | 1 (0.3) | 2 (0.6) |