Nonhematologic side effects with PEG IFN-α-2b
| Dose level (μg/kg/wk) . | No. . | Fatigue, aches . | Depression 2 . | Neurotoxicity . | Fever, flu 2 . | Liver abnormalities . | Weight loss 1-2 . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| 2 . | 3-4 . | 2 . | 3-4 . | 2 . | 3-4 . | |||||
| 0.75 | 3 | |||||||||
| 1.5 | 3 | 1 | ||||||||
| 3 | 3 | 1 | 1 | 1 | 1 | |||||
| 4.5 | 3 | 1 | 1 | |||||||
| 6 | 3 | 1 | 1 | 1 | 1 | |||||
| 7.5 | 6 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 9 | 6 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | |
| Dose level (μg/kg/wk) . | No. . | Fatigue, aches . | Depression 2 . | Neurotoxicity . | Fever, flu 2 . | Liver abnormalities . | Weight loss 1-2 . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| 2 . | 3-4 . | 2 . | 3-4 . | 2 . | 3-4 . | |||||
| 0.75 | 3 | |||||||||
| 1.5 | 3 | 1 | ||||||||
| 3 | 3 | 1 | 1 | 1 | 1 | |||||
| 4.5 | 3 | 1 | 1 | |||||||
| 6 | 3 | 1 | 1 | 1 | 1 | |||||
| 7.5 | 6 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 9 | 6 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | |
Number of patients with toxicity grade is shown under each toxicity column.