Table 3. Correlation between liver... | American Society of Hematology

Table 3.

Correlation between liver status and epidemiologic and clinical features of the 88 HCV-RNA–positive hemophilic patients

Features	Normal ALT levels (n = 15)	Chronic hepatitis (n = 61)	Severe liver disease^3-150 (n = 12)	P^3-151
Median age, y (range)	43.1 (15-67)	44.6 (25-70)	52.1 (26-68)	.02
Median age at infection, y (range)	22.3 (1-56)	19.6 (1-52)	22.0 (1-42)	NS
Median duration of infection, y (range)	21.1 (15-32)	25.0 (15-50)	29.6 (15-36)	.03
Sex
Male	13 (86.7)^3-152	52 (85.2)^3-152	10 (83.3)^3-152	NS
Female	2 (13.3)^3-152	9 (14.7)^3-152	2 (16.7)^3-152
Diagnosis
Mild/moderate hemophilia	8 (53.3)^3-152	30 (49.2)^3-152	3 (25.0)^3-152	< .01
Severe hemophilia	3 (20.0)^3-152	21 (34.4)^3-152	7 (58.3)^3-152	< .001
von Willebrand disease	4 (26.7)^3-152	10 (16.4)^3-152	2 (16.7)^3-152	NS

Features	Normal ALT levels (n = 15)	Chronic hepatitis (n = 61)	Severe liver disease^3-150 (n = 12)	P^3-151
Median age, y (range)	43.1 (15-67)	44.6 (25-70)	52.1 (26-68)	.02
Median age at infection, y (range)	22.3 (1-56)	19.6 (1-52)	22.0 (1-42)	NS
Median duration of infection, y (range)	21.1 (15-32)	25.0 (15-50)	29.6 (15-36)	.03
Sex
Male	13 (86.7)^3-152	52 (85.2)^3-152	10 (83.3)^3-152	NS
Female	2 (13.3)^3-152	9 (14.7)^3-152	2 (16.7)^3-152
Diagnosis
Mild/moderate hemophilia	8 (53.3)^3-152	30 (49.2)^3-152	3 (25.0)^3-152	< .01
Severe hemophilia	3 (20.0)^3-152	21 (34.4)^3-152	7 (58.3)^3-152	< .001
von Willebrand disease	4 (26.7)^3-152	10 (16.4)^3-152	2 (16.7)^3-152	NS

HCV indicates hepatitis C virus; ALT, alanine aminotransferase; NS, not significant.

Severe liver disease = liver cirrhosis, hepatic decompensation, and hepatocellular carcinoma.

P value = severe liver disease versus normal ALT levels and chronic hepatitis.

Number (percentage).