Table 1. Epidemiologic, clinical, and... | American Society of Hematology

Table 1.

Epidemiologic, clinical, and virologic features of the 102 HCV antibody–positive hemophiliacs

Features	HCV antibody–positive hemophiliacs (n = 102)
Median age, y (range)	45.1 (15-71)
Median age at infection, y (range)	20.1 (1-56)
Median duration of infection, y (range)	25.1 (15-34)
Sex
Male	88 (86.3)^*
Female	14 (13.7)^*
Diagnosis
Mild/moderate hemophilia	48 (47.1)^*
Severe hemophilia	34 (33.3)^*
von Willebrand disease	20 (19.6)^*
HCV genotype^†
1a	18 (20.5)^*
1b	32 (36.4)^*
2	15 (17.0)^*
3	14 (15.9)^*
4	3 (3.4)^*
1a + 1b	5 (5.7)^*
1a + 2	1 (1.1)^*
Liver status
Normal ALT levels^‡	29 (28.4)^*
Chronic hepatitis	61 (59.8)^*
Liver cirrhosis	6 (5.9)^*
Hepatic decompensation	4 (3.9)^*
Hepatocellular carcinoma	2 (2.0)^*

Features	HCV antibody–positive hemophiliacs (n = 102)
Median age, y (range)	45.1 (15-71)
Median age at infection, y (range)	20.1 (1-56)
Median duration of infection, y (range)	25.1 (15-34)
Sex
Male	88 (86.3)^*
Female	14 (13.7)^*
Diagnosis
Mild/moderate hemophilia	48 (47.1)^*
Severe hemophilia	34 (33.3)^*
von Willebrand disease	20 (19.6)^*
HCV genotype^†
1a	18 (20.5)^*
1b	32 (36.4)^*
2	15 (17.0)^*
3	14 (15.9)^*
4	3 (3.4)^*
1a + 1b	5 (5.7)^*
1a + 2	1 (1.1)^*
Liver status
Normal ALT levels^‡	29 (28.4)^*
Chronic hepatitis	61 (59.8)^*
Liver cirrhosis	6 (5.9)^*
Hepatic decompensation	4 (3.9)^*
Hepatocellular carcinoma	2 (2.0)^*

HCV indicates hepatitis C virus; ALT, alanine aminotransferase.

Number (percentage).

HCV genotype was performed on the 88 HCV-RNA–positive patients.

Among the patients with normal ALT levels, 14 (13.7%) were HCV-RNA negative and 15 (14.7%) were HCV-RNA positive.