Table 2. Results of direct sequencing... | American Society of Hematology

Table 2.

Results of direct sequencing performed in patients with p53 deletion or protein expression or both

Patient code	p53 deletion (% nuclei)	Protein expression	Direct sequencing
Patient code	p53 deletion (% nuclei)	Protein expression	Exon	Codon	Mutation/polymorphism	Amino acid substitution
A	50	No	4	72	CGC to CCC	Arg to Pro
B	No deletion	Yes			No mutation found
C(1994)	No deletion	No			No mutation found
(1997)	15	No			No mutation found
(1998)	60	No			No mutation found
D	83	No			No DNA available
E	75	No			No DNA available
F	65	No	4	32	CCG to CCA	Not altered
			4	72	CGC to CCC	Arg to Pro
G	70	No			No mutation found
I	44	No	4	72	CGC to CCC	Arg to Pro
J(1997)	80	Yes	8	273	CGT to CAT^*	Arg to His
(1999)	88	Yes	8	273	CGT to CAT^†	Arg to His
K	91	No			No mutation found
L	56	Yes	8	262-263	6-bp deletion (GGTAAT)^*	Gly-Asn deleted

Patient code	p53 deletion (% nuclei)	Protein expression	Direct sequencing
Patient code	p53 deletion (% nuclei)	Protein expression	Exon	Codon	Mutation/polymorphism	Amino acid substitution
A	50	No	4	72	CGC to CCC	Arg to Pro
B	No deletion	Yes			No mutation found
C(1994)	No deletion	No			No mutation found
(1997)	15	No			No mutation found
(1998)	60	No			No mutation found
D	83	No			No DNA available
E	75	No			No DNA available
F	65	No	4	32	CCG to CCA	Not altered
			4	72	CGC to CCC	Arg to Pro
G	70	No			No mutation found
I	44	No	4	72	CGC to CCC	Arg to Pro
J(1997)	80	Yes	8	273	CGT to CAT^*	Arg to His
(1999)	88	Yes	8	273	CGT to CAT^†	Arg to His
K	91	No			No mutation found
L	56	Yes	8	262-263	6-bp deletion (GGTAAT)^*	Gly-Asn deleted

Heterozygous mutation.

Homozygous mutation.