Clinical, cytogenetic, and comparative genomic hybridization features of 19 patients with lymphocyte predominance Hodgkin disease
| Case . | Sex/age* . | Status† . | Clinical stage‡ . | Karyotype1-153 . | CGH1-153 Rev ish . |
|---|---|---|---|---|---|
| 1 | M/10 | PD | IIIA | ND | enh(1p32p12,3,4q,5p15q13,6q,8,10p12q23,12,20p,Xq22q26), dim(2,5q21q35,6p25p23,7,9,11q,13,16,17) |
| 2 | F/37 | PD | IA | ND | enh(1,2q,3,7,12q,16,18q11q21),dim(4q24q25,5q31q35,6,8p23q21, 10,11,13,20,21,Xp),amp(1q) |
| 3 | F/71 | PD | IA | 46,XX [11] | enh(5p13q35,20p),dim(11q) |
| 4 | M/30 | PD | IIA | NM | enh(3p14q13,5p14q12,6,9p,X),dim(1p,11q) |
| 5 | M/67 | PD | IIA | 46,XY [11] | enh(1,3p26p21,5q14q23,6p,7p,8p12q24,11p15q22,Xq) |
| 6 | M/25 | PD | IA | 46,XY [10] | enh(1p,3,6q,8,10,11,13,18q,X),dim(17p) |
| 7 | M/49 | PD | IA | 82-86,XXYY,4-7mar[inc2]/46,XY [4] | enh(3q,4q,11,Xq) |
| 8 | M/33 | PD | IIA | ND | enh(1q21q31,5p15q23,7,11,14q11q21,X),dim(8p,16,17,20q) |
| 9 | M/25 | PD | IA | 43,X,−Y,i(1)(q10),t(3;22)(q27;q12),−4,add(7)(q36), −10,−17,+mar[4]/46,XY[6] | enh(1q,5q,6,10q22q24,20p,Xq23q27),dim(1p,4,10p,17,Xp22p21) |
| 10 | M/33 | PD | IIA | NM | enh(1q,3,4q23q27,6,8q,11q,X),dim(16p,17) |
| 11a | M/441-155 | 1.R | II | ND | enh(2q21q34,3p,4q,5q14q23,6q,8q,11,12q,13,20p,X) |
| 11b | 2.R | IVA | ND | enh(2q21q34,3p,4q,5q14q23,6q,8q,11,12q,13,20p,X) | |
| 12 | M/44 | PD | IA | ND | enh(1q,2q24q34,3,4q12q25,5q,6p,8q,12q,X) |
| 13 | M/37 | R | IIA | ND | enh(2,5q12q23,6q12q24,9q,12q),dim(3,10p15q22,17) |
| 14 | M/27 | PD | NA | 46,XY [7] | enh(1,2,5q23q35,15,20,X),dim(4p16p15,6p,7p,8,18) |
| R | NA | 92,XX,YY,+X,−1,−2,?del(2)(q34),der(3)t(3;?;1) | |||
| (q27;?;q21)x2,add(4)(p15)x3,−5,+6,?der(6) | |||||
| del(6)(p21.3p21.2)del(6)(p23)x3,del(7)(p11)x2,−10, −10,−12,−13,−13,−14,−16,+17,−18,−18, −19[1]/46,XY[16]/92,XXYY[3] | |||||
| 15 | M/521-155 | R | IIA | NM | enh(1q,2,3,4,5q,7p15p11,10p15p13,12q12q15,13,18p,21), dim(1p,5p,6q23q27,7q31q36,9,10q,11q12q23,15,16p,17,18q), amp(13) |
| 16 | M/74 | PD | IIA | ND | enh(1p36q31,2q14q31,4q,5q,8q,X),dim(9q31q34,17,20q) |
| 17 | M/42 | PD | II | 42,X,−Y,del(1)(p12),+del(1)(p12),add(2)(p25),−11, −12,−13,−14 [1]/47,XY,+X [1]/46,XY [1] | enh(1q,2p,3,4q,6,8,11,12q,X) |
| 18 | M/28 | PD | IIIA | NM | enh(2p,4p15q22,Xp),dim(6p,8p,10p) |
| 19 | M/11 | PD | IIA | 46,XY [4] | enh(1p22q44,3p21p13,4q,5p,6,7p,8q21,9q13q22,12p13q12, 12q14q24,13,14q11q24,21,Xp),dim(2,5q13q35,10q22q26,11p, 15,16p,18p11q21,Xq21q28),amp(5p14,6q22,Xp21) |
| Case . | Sex/age* . | Status† . | Clinical stage‡ . | Karyotype1-153 . | CGH1-153 Rev ish . |
|---|---|---|---|---|---|
| 1 | M/10 | PD | IIIA | ND | enh(1p32p12,3,4q,5p15q13,6q,8,10p12q23,12,20p,Xq22q26), dim(2,5q21q35,6p25p23,7,9,11q,13,16,17) |
| 2 | F/37 | PD | IA | ND | enh(1,2q,3,7,12q,16,18q11q21),dim(4q24q25,5q31q35,6,8p23q21, 10,11,13,20,21,Xp),amp(1q) |
| 3 | F/71 | PD | IA | 46,XX [11] | enh(5p13q35,20p),dim(11q) |
| 4 | M/30 | PD | IIA | NM | enh(3p14q13,5p14q12,6,9p,X),dim(1p,11q) |
| 5 | M/67 | PD | IIA | 46,XY [11] | enh(1,3p26p21,5q14q23,6p,7p,8p12q24,11p15q22,Xq) |
| 6 | M/25 | PD | IA | 46,XY [10] | enh(1p,3,6q,8,10,11,13,18q,X),dim(17p) |
| 7 | M/49 | PD | IA | 82-86,XXYY,4-7mar[inc2]/46,XY [4] | enh(3q,4q,11,Xq) |
| 8 | M/33 | PD | IIA | ND | enh(1q21q31,5p15q23,7,11,14q11q21,X),dim(8p,16,17,20q) |
| 9 | M/25 | PD | IA | 43,X,−Y,i(1)(q10),t(3;22)(q27;q12),−4,add(7)(q36), −10,−17,+mar[4]/46,XY[6] | enh(1q,5q,6,10q22q24,20p,Xq23q27),dim(1p,4,10p,17,Xp22p21) |
| 10 | M/33 | PD | IIA | NM | enh(1q,3,4q23q27,6,8q,11q,X),dim(16p,17) |
| 11a | M/441-155 | 1.R | II | ND | enh(2q21q34,3p,4q,5q14q23,6q,8q,11,12q,13,20p,X) |
| 11b | 2.R | IVA | ND | enh(2q21q34,3p,4q,5q14q23,6q,8q,11,12q,13,20p,X) | |
| 12 | M/44 | PD | IA | ND | enh(1q,2q24q34,3,4q12q25,5q,6p,8q,12q,X) |
| 13 | M/37 | R | IIA | ND | enh(2,5q12q23,6q12q24,9q,12q),dim(3,10p15q22,17) |
| 14 | M/27 | PD | NA | 46,XY [7] | enh(1,2,5q23q35,15,20,X),dim(4p16p15,6p,7p,8,18) |
| R | NA | 92,XX,YY,+X,−1,−2,?del(2)(q34),der(3)t(3;?;1) | |||
| (q27;?;q21)x2,add(4)(p15)x3,−5,+6,?der(6) | |||||
| del(6)(p21.3p21.2)del(6)(p23)x3,del(7)(p11)x2,−10, −10,−12,−13,−13,−14,−16,+17,−18,−18, −19[1]/46,XY[16]/92,XXYY[3] | |||||
| 15 | M/521-155 | R | IIA | NM | enh(1q,2,3,4,5q,7p15p11,10p15p13,12q12q15,13,18p,21), dim(1p,5p,6q23q27,7q31q36,9,10q,11q12q23,15,16p,17,18q), amp(13) |
| 16 | M/74 | PD | IIA | ND | enh(1p36q31,2q14q31,4q,5q,8q,X),dim(9q31q34,17,20q) |
| 17 | M/42 | PD | II | 42,X,−Y,del(1)(p12),+del(1)(p12),add(2)(p25),−11, −12,−13,−14 [1]/47,XY,+X [1]/46,XY [1] | enh(1q,2p,3,4q,6,8,11,12q,X) |
| 18 | M/28 | PD | IIIA | NM | enh(2p,4p15q22,Xp),dim(6p,8p,10p) |
| 19 | M/11 | PD | IIA | 46,XY [4] | enh(1p22q44,3p21p13,4q,5p,6,7p,8q21,9q13q22,12p13q12, 12q14q24,13,14q11q24,21,Xp),dim(2,5q13q35,10q22q26,11p, 15,16p,18p11q21,Xq21q28),amp(5p14,6q22,Xp21) |
CGH indicates comparative genomic hybridization; Rev ish, reverse in situ hybridization; PD, primary diagnosis; ND, no data; R, relapse; NA, not available; NM, no mitosis.
Age at the time of primary diagnosis.
Status at the time of lymph node biopsy.
Clinical stage according to the Ann Arbor classification.
Cytogenetic and CGH results are described according to the ISCN nomenclature.
Death disease related.