Frequency of cytogenetic and molecular subgroups of APL
| Cytogenetic/molecular abnormality . | Number of cases (%) (n = 611) . |
|---|---|
| t(15;17) | 559 (91.5%) |
| ider(17q) | 10 (1.6%) |
| Uncharacterized (normal chromosomes 15 and 17) | 7 (1.1%) |
| No t(15;17), underlying PML/RARαrearrangement | 33 (5.4%) |
| Insertions | 22 (3.6%) |
| Complex chromosomal rearrangements | 11 (1.8%) |
| t(11;17)(q23;q21) and/or PLZF-RARα fusion | 5 (0.8%) |
| t(5;17) | 2 (0.4%) |
| NPM/RARα rearrangement | 1 (0.2%) |
| NPM/RARαnegative | 1 (0.2%) |
| RARα not rearranged | 5 (0.8%) |
| Cytogenetic/molecular abnormality . | Number of cases (%) (n = 611) . |
|---|---|
| t(15;17) | 559 (91.5%) |
| ider(17q) | 10 (1.6%) |
| Uncharacterized (normal chromosomes 15 and 17) | 7 (1.1%) |
| No t(15;17), underlying PML/RARαrearrangement | 33 (5.4%) |
| Insertions | 22 (3.6%) |
| Complex chromosomal rearrangements | 11 (1.8%) |
| t(11;17)(q23;q21) and/or PLZF-RARα fusion | 5 (0.8%) |
| t(5;17) | 2 (0.4%) |
| NPM/RARα rearrangement | 1 (0.2%) |
| NPM/RARαnegative | 1 (0.2%) |
| RARα not rearranged | 5 (0.8%) |