Table 1. Study design of KF41399 effects... | American Society of Hematology

Table 1.

Study design of KF41399 effects on ACNU-induced thrombocytopenia

Protocol	KF41399			ACNU
Protocol	Dose^* (mg/kg)	Schedule (day)	Frequency	Dose^† (mg/kg)	Schedule (day)	Frequency
A	None			None
B	0.2, 1, 5, 25	0-2	BID	None
C	25	0-2	BID	None
D	25	0-2	BID	45	3-4	Daily
E	25	2-4	BID	45	3-4	Daily
F	25	4-6	BID	45	3-4	Daily
G	0.2, 1, 5, 25	0-2	BID	45	3-4	Daily
H	25	0-9	BID	45	3-4	Daily
I	None			45	3-4	Daily

Protocol	KF41399			ACNU
Protocol	Dose^* (mg/kg)	Schedule (day)	Frequency	Dose^† (mg/kg)	Schedule (day)	Frequency
A	None			None
B	0.2, 1, 5, 25	0-2	BID	None
C	25	0-2	BID	None
D	25	0-2	BID	45	3-4	Daily
E	25	2-4	BID	45	3-4	Daily
F	25	4-6	BID	45	3-4	Daily
G	0.2, 1, 5, 25	0-2	BID	45	3-4	Daily
H	25	0-9	BID	45	3-4	Daily
I	None			45	3-4	Daily

Oral;

intravenous; BID, twice daily.

N = 5 in each group.