Clonal Cytogenetic Abnormalities and ALL Immunophenotype
| Abnormality . | B . | BMy . | T . | TMy . | B-LIN . | T-LIN . | Total . |
|---|---|---|---|---|---|---|---|
| No. of cases | 69 | 24 | 14 | 4 | 93 | 18 | 111 |
| t(9;22)7-150 | 13 | 10 | 0 | 0 | 23 | 0 | 23 |
| Any 11q23 | 14 | 1 | 0 | 0 | 15 | 0 | 15 |
| t(4;11) | 12 | 1 | 0 | 0 | 13 | 0 | 13 |
| +21 | 9 | 4 | 0 | 1 | 13 | 1 | 14 |
| +8 | 7 | 3 | 0 | 0 | 10 | 0 | 10 |
| 14q32 | 6 | 2 | 0 | 0 | 8 | 0 | 8 |
| −7 | 3 | 3 | 0 | 0 | 6 | 0 | 6 |
| del 9p | 4 | 0 | 1 | 0 | 4 | 1 | 5 |
| Other abnormality | 15 | 4 | 3 | 2 | 19 | 5 | 24 |
| Normal | 15 | 6 | 10 | 1 | 21 | 11 | 32 |
| Abnormality . | B . | BMy . | T . | TMy . | B-LIN . | T-LIN . | Total . |
|---|---|---|---|---|---|---|---|
| No. of cases | 69 | 24 | 14 | 4 | 93 | 18 | 111 |
| t(9;22)7-150 | 13 | 10 | 0 | 0 | 23 | 0 | 23 |
| Any 11q23 | 14 | 1 | 0 | 0 | 15 | 0 | 15 |
| t(4;11) | 12 | 1 | 0 | 0 | 13 | 0 | 13 |
| +21 | 9 | 4 | 0 | 1 | 13 | 1 | 14 |
| +8 | 7 | 3 | 0 | 0 | 10 | 0 | 10 |
| 14q32 | 6 | 2 | 0 | 0 | 8 | 0 | 8 |
| −7 | 3 | 3 | 0 | 0 | 6 | 0 | 6 |
| del 9p | 4 | 0 | 1 | 0 | 4 | 1 | 5 |
| Other abnormality | 15 | 4 | 3 | 2 | 19 | 5 | 24 |
| Normal | 15 | 6 | 10 | 1 | 21 | 11 | 32 |
B-LIN combines B and BMy cases, whereas T-LIN combines T and TMy cases. Many patients were found to have more than one karyotypic abnormality and are therefore included in more than one category. Patients with t(8;14) were not included in this study.
t(9;22) confirmed by cytogenetic analysis only. There were 4 B-LIN cases lacking cytogenetic evidence of t(9;22) that were BCR-ABL+. Additionally, 1 T-LIN case and 16 B-LIN cases were BCR-ABL+ but not evaluated cytogenetically.