Single (n = 19) and Combined (n = 8) Prothrombotic Risk Factors Found Among 32 Symptomatic Children With ALL (Absolute and Relative Frequencies)
| . | MTHFR (+/+) . | P G20210A (+/−) . | (+/−) FV: G1691A . | Lp(a) ↑ . | Protein C . | Protein S . | Antithrombin . | No Defect So Far . |
|---|---|---|---|---|---|---|---|---|
| MTHFR | 4 (12.5%) | — | 1 (3.1%) | 2 (6.3%) | — | — | — | |
| P G20210A | — | 1 (3.1%) | — | — | — | — | — | |
| FV: G1691A | 1 (3.1%) | — | 3 (9.4%) | 2 (6.3%) | 1 (3.1%) | — | — | |
| Lp(a) ↑ | 2 (6.3%) | — | 2 (6.3%) | 2 (6.3%) | 2 (6.3%) | — | — | |
| Protein C | — | — | 1 (3.1%) | 2 (6.3%) | 3 (9.4%) | — | — | |
| Protein S | — | — | — | — | — | 4 (12.5%) | — | |
| Antithrombin | — | — | — | — | — | — | 2 (6.3%) | |
| No defect | 5 (15.6%) |
| . | MTHFR (+/+) . | P G20210A (+/−) . | (+/−) FV: G1691A . | Lp(a) ↑ . | Protein C . | Protein S . | Antithrombin . | No Defect So Far . |
|---|---|---|---|---|---|---|---|---|
| MTHFR | 4 (12.5%) | — | 1 (3.1%) | 2 (6.3%) | — | — | — | |
| P G20210A | — | 1 (3.1%) | — | — | — | — | — | |
| FV: G1691A | 1 (3.1%) | — | 3 (9.4%) | 2 (6.3%) | 1 (3.1%) | — | — | |
| Lp(a) ↑ | 2 (6.3%) | — | 2 (6.3%) | 2 (6.3%) | 2 (6.3%) | — | — | |
| Protein C | — | — | 1 (3.1%) | 2 (6.3%) | 3 (9.4%) | — | — | |
| Protein S | — | — | — | — | — | 4 (12.5%) | — | |
| Antithrombin | — | — | — | — | — | — | 2 (6.3%) | |
| No defect | 5 (15.6%) |
Single and combined conditions predisposing for thrombosis (absolute numbers and relative frequencies) found among 32 out of 289 symptomatic children with ALL and thromboembolism during the ALL-BFM study protocols. In 5 children with thromboembolism no prothrombotic defect within the hemostatic system has been identified so far.