Primary Nodal, Extranodal, and Extensive LCL: Clinical Presentation Versus Rearrangement of BCL2, BCL6, or MYC
| Patient No. . | Site of Presentation . | Stage . | Lymph Node . | Spleen . | Marrow . | Other Sites . | BCL2 Protein Expression . | Oncogene Rearrangement . |
|---|---|---|---|---|---|---|---|---|
| Nodal | ||||||||
| 1 | Spleen | I | − | + | − | − | − | − |
| 2 | Nasopharynx | I | + | − | − | − | + | − |
| 3 | Tonsil | I | − | − | − | − | + | −-150 |
| 4 | Lymph node | I | + | − | − | − | + | −-150 |
| 5 | Lymph node | I | + | − | − | − | − | − |
| 6 | Lymph node | I | + | − | − | − | − | − |
| 7 | Lymph node | I? | + | − | NT | − | − | − |
| 8 | Lymph node | I | + | − | − | − | − | − |
| 9 | Lymph node | I | + | − | − | − | + | − |
| 10 | Lymph node | I | + | − | − | − | − | − |
| 11 | Lymph node | I | + | − | − | − | + | − |
| 12 | Lymph node | I | + | − | − | − | + | −-151 |
| 13 | Tonsil | I | − | − | − | − | + | BCL6 |
| 14 | Lymph node | I | + | − | − | − | − | BCL6 |
| 15 | Lymph node | I? | + | − | NT | − | − | BCL6 |
| 16 | Lymph node | I | + | − | − | − | − | BCL6 |
| 17 | Lymph node | I | + | − | − | − | − | BCL6 |
| 18 | Lymph node | I | + | − | − | − | + | MYC-151 |
| 19 | Spleen | II | − | + | − | Pancreas tail | − | − |
| 20 | Lymph node | II | + | − | − | Tonsil | + | − |
| 21 | Lymph node | II | + | − | − | − | − | − |
| 22 | Lymph node | II | + | − | − | − | − | − |
| 23 | Lymph node | II | + | − | − | − | + | − |
| 24 | Lymph node | II | + | − | − | Tonsil | + | − |
| 25 | Lymph node | II? | + | − | NT | − | + | − |
| 26 | Lymph node | II | + | − | − | Tonsil | − | − |
| 27 | Lymph node | II | + | + | − | − | − | − |
| 28 | Lymph node | II? | + | − | NT | Hypopharynx | − | − |
| 29 | Lymph node | II | + | − | − | − | − | − |
| 30 | Lymph node | II | + | − | − | − | − | − |
| 31 | Lymph node | II | + | − | − | Tonsil | − | − |
| 32 | Lymph node | II | + | − | − | − | − | −-150,-151 |
| 33 | Lymph node | II | + | − | − | Tonsil | − | −-151 |
| 34 | Lymph node | II | + | − | − | Pleura | + | − |
| 35 | Lymph node | II | + | − | − | − | + | BCL2 |
| 36 | Lymph node | II | + | − | − | − | − | BCL2-151 |
| 37 | Lymph node | II | + | − | − | Tonsil | − | BCL2-151 |
| 38 | Lymph node | II | + | − | − | − | − | BCL2-151 |
| 39 | Lymph node | II | + | − | − | Tonsil | + | BCL2 |
| 40 | Lymph node | II | + | − | − | − | + | BCL2 |
| 41 | Lymph node | II | + | − | − | Tonsil | − | BCL2-151 |
| 42 | Lymph node | II | + | − | − | − | + | BCL2-151 |
| 43 | Lymph node | II | + | − | − | − | − | BCL2/BCL6 |
| 44 | Lymph node | II? | + | − | NT | − | − | BCL6 |
| 45 | Lymph node | II | + | + | − | − | − | BCL6 |
| 46 | Lymph node | II | + | − | − | Tongue | − | BCL6 |
| 47 | Lymph node | II | + | − | − | − | + | BCL6 |
| 48 | Lymph node | II | + | − | − | Tonsil | − | BCL6 |
| 49 | Lymph node | III | +/+ | − | − | − | − | − |
| 50 | Lymph node | III | +/+ | − | − | − | − | − |
| 51 | Lymph node | III | +/+ | − | − | Hypopharynx | + | − |
| 52 | Lymph node | III | +/+ | − | − | − | − | − |
| 53 | Lymph node | III | +/+ | − | − | − | − | −-151 |
| 54 | Lymph node | III | +/+ | − | − | Thyroid gland | − | −-151 |
| 55 | Lymph node | III | +/+ | − | − | − | − | − |
| 56 | Lymph node | III | +/+ | − | − | − | − | − |
| 57 | Lymph node | III | +/+ | − | − | − | − | − |
| 58 | Lymph node | III | +/+ | − | − | − | − | − |
| 59 | Lymph node | III | +/+ | − | − | Tonsil | + | − |
| 60 | Lymph node | III | +/+ | − | − | − | − | − |
| 61 | Lymph node | III? | +/+ | − | NT | Tonsil | + | − |
| 62 | Lymph node | III | +/+ | − | − | − | − | − |
| 63 | Lymph node | III? | +/+ | − | NT | − | + | BCL2 |
| 64 | Lymph node | III | +/+ | − | − | − | − | BCL2-151 |
| 65 | Lymph node | III | +/+ | − | − | Tonsil | + | BCL2/BCL6 |
| 66 | Lymph node | III | +/+ | − | − | − | − | BCL6 |
| 67 | Lymph node | III? | +/+ | − | NT | − | + | BCL6 |
| 68 | Lymph node | III? | +/+ | − | NT | − | − | BCL6 |
| 69 | Lymph node | III | +/+ | − | − | − | + | BCL6 |
| 70 | Lymph node | III | +/+ | − | − | − | − | BCL6 |
| 71 | Lymph node | III | +/+ | − | − | − | − | BCL6 |
| 72 | Lymph node | III | +/+ | − | − | − | − | BCL6/MYC |
| 73 | Lymph node | IV | + | + | + | − | − | − |
| 74 | Lymph node | IV | + | − | + | − | + | −-151 |
| 75 | Lymph node | IV | + | − | + | − | + | − |
| 76 | Lymph node | IV | + | − | − | Liver | + | − |
| 77 | Lymph node | IV | + | − | + | Tonsil | − | −-151 |
| 78 | Lymph node | IV | +/+ | + | + | Liver | − | −-151 |
| 79 | Lymph node | IV | + | − | + | − | + | −-151 |
| 80 | Lymph node | IV | + | − | + | − | + | − |
| 81 | Lymph node | IV | + | − | + | Tonsil | + | − |
| 82 | Lymph node | IV | + | − | + | − | − | −-151 |
| 83 | Lymph node | IV | +/+ | + | + | − | − | − |
| 84 | Lymph node | IV | +/+ | − | − | Liver | − | −-151 |
| 85 | Lymph node | IV | +/+ | + | + | − | + | − |
| 86 | Lymph node | IV | + | − | + | − | + | − |
| 87 | Spleen | IV | − | + | + | − | − | − |
| 88 | Lymph node | IV | +/+ | + | − | Pleura | + | BCL2 |
| 89 | Lymph node | IV | +/+ | − | + | − | + | BCL2-150 |
| 90 | Lymph node | IV | +/+ | + | + | − | + | BCL2 |
| 91 | Lymph node | IV | +/+ | − | + | − | − | BCL2-151 |
| 92 | Lymph node | IV | +/+ | + | + | − | + | BCL6 |
| 93 | Lymph node | IV | +/+ | − | + | − | − | BCL6 |
| Extranodal | ||||||||
| 94 | Bone | I | − | − | − | − | + | − |
| 95 | Bone | I | − | − | − | − | − | − |
| 96 | Skin | I | − | − | − | − | − | − |
| 97 | Stomach | I | − | − | − | − | − | −-151 |
| 98 | Stomach | I | − | − | − | − | + | −-151 |
| 99 | Soft tissue | I | − | − | − | − | − | −-151 |
| 100 | Ethmoid sinus | I | − | − | − | − | + | −-151 |
| 101 | Lacrimal gland | I | − | − | − | − | − | − |
| 102 | Submandibular gland | I | − | − | − | − | − | |
| 103 | Parotic gland | I | − | − | − | − | − | − |
| 104 | Thyroid gland | I? | − | − | NT | − | + | − |
| 105 | Testis | I? | − | − | NT | − | + | −-151 |
| 106 | Breast | I | − | − | − | − | − | − |
| 107 | Breast | I | − | − | − | − | + | − |
| 108 | Breast | I? | − | − | NT | − | + | BCL6 |
| 109 | Breast | I | − | − | − | − | + | BCL6 |
| 110 | Soft tissue | I | − | − | − | − | − | BCL6 |
| 111 | CNS | I | − | − | − | − | − | BCL6 |
| 112 | Stomach | I | − | − | − | − | − | BCL6 |
| 113 | Stomach | I | − | − | − | − | − | MYC-151 |
| 114 | Stomach | I | − | − | − | − | − | MYC-151 |
| 115 | Stomach | I | − | − | − | − | + | MYC-151 |
| 116 | Colon | II | + | − | − | − | + | − |
| 117 | Kidney | II | + | − | − | − | − | − |
| 118 | Appendix | II | + | − | − | − | − | −-151 |
| 119 | Small intestine | II | + | − | − | − | + | − |
| 120 | Thyroid gland | II | + | − | − | − | − | BCL2-151 |
| 121 | Colon | II | + | − | − | − | + | BCL2/BCL6 |
| 122 | Skin | II | + | − | − | − | − | BCL6 |
| 123 | Small intestine | II | + | − | − | − | + | BCL6 |
| 124 | Stomach | II | + | − | − | − | − | MYC-151 |
| 125 | Stomach | II? | + | − | NT | − | − | MYC-151 |
| 126 | Soft tissue | II | + | − | − | − | − | MYC-151 |
| 127 | Stomach | IV | + | − | − | Liver | − | −-151 |
| 128 | Stomach | IV | + | − | + | Esophagus | − | −-151 |
| 129 | Small intestine | IV | + | − | − | Peritoneum | − | − |
| 130 | Suprarenal gland | IV | + | − | − | Peritoneum | − | − |
| 131 | Colon | IV | − | − | + | − | − | − |
| 132 | Small intestine | IV | − | − | + | Sigmoid | + | − |
| 133 | Soft tissue | IV | − | − | − | Pleura | − | − |
| 134 | Liver | IV | + | − | NT | − | + | − |
| 135 | Testis | IV | + | − | + | − | + | −-151 |
| 136 | Bone | IV | − | − | + | − | + | BCL6 |
| 137 | CNS | IV | − | − | NT | Epidural | − | BCL6 |
| 138 | Lung | IV | − | − | + | Pleura | − | MYC-151 |
| Extensive | ||||||||
| 139 | Extensive | IV | + | − | + | CNS | − | −-151 |
| 140 | Extensive | IV | +/+ | − | + | Liver | + | − |
| 141 | Extensive | IV | + | − | + | Lung | − | − |
| 142 | Extensive | IV | +/+ | − | + | Pleura | + | − |
| 143 | Extensive | IV | +/+ | + | + | Liver | + | − |
| 144 | Extensive | IV | +/+ | − | − | Stomach, pleura | − | −-151 |
| peritoneum | ||||||||
| 145 | Extensive | IV | +/+ | + | − | Pleura, peritoneum | − | BCL2 |
| 146 | Extensive | IV | + | − | − | Breast | + | BCL2-151 |
| 147 | Extensive | IV | +/+ | + | + | Soft tissue | + | BCL2-151 |
| 148 | Extensive | IV | +/+ | − | − | Small intestine, parotic gland, pleura | + | BCL2-150 |
| 149 | Extensive | IV | +/+ | − | NT | CNS, liver | − | BCL2-151 |
| 150 | Extensive | IV | + | − | − | Liver, soft tissue | − | BCL2 |
| 151 | Extensive | IV | +/+ | − | − | Breast | − | BCL2 |
| 152 | Extensive | IV | +/+ | − | − | CNS, soft tissue | − | BCL6 |
| 153 | Extensive | IV | + | + | − | Kidney, pleura | + | BCL6 |
| 154 | Extensive | IV | +/+ | − | NT | Lung, pleura | − | BCL6 |
| 155 | Extensive | IV | +/+ | − | − | Small intestine | − | BCL6 |
| 156 | Extensive | IV | +/+ | − | + | Testis, lung, pleura | + | BCL6/MYC |
| Patient No. . | Site of Presentation . | Stage . | Lymph Node . | Spleen . | Marrow . | Other Sites . | BCL2 Protein Expression . | Oncogene Rearrangement . |
|---|---|---|---|---|---|---|---|---|
| Nodal | ||||||||
| 1 | Spleen | I | − | + | − | − | − | − |
| 2 | Nasopharynx | I | + | − | − | − | + | − |
| 3 | Tonsil | I | − | − | − | − | + | −-150 |
| 4 | Lymph node | I | + | − | − | − | + | −-150 |
| 5 | Lymph node | I | + | − | − | − | − | − |
| 6 | Lymph node | I | + | − | − | − | − | − |
| 7 | Lymph node | I? | + | − | NT | − | − | − |
| 8 | Lymph node | I | + | − | − | − | − | − |
| 9 | Lymph node | I | + | − | − | − | + | − |
| 10 | Lymph node | I | + | − | − | − | − | − |
| 11 | Lymph node | I | + | − | − | − | + | − |
| 12 | Lymph node | I | + | − | − | − | + | −-151 |
| 13 | Tonsil | I | − | − | − | − | + | BCL6 |
| 14 | Lymph node | I | + | − | − | − | − | BCL6 |
| 15 | Lymph node | I? | + | − | NT | − | − | BCL6 |
| 16 | Lymph node | I | + | − | − | − | − | BCL6 |
| 17 | Lymph node | I | + | − | − | − | − | BCL6 |
| 18 | Lymph node | I | + | − | − | − | + | MYC-151 |
| 19 | Spleen | II | − | + | − | Pancreas tail | − | − |
| 20 | Lymph node | II | + | − | − | Tonsil | + | − |
| 21 | Lymph node | II | + | − | − | − | − | − |
| 22 | Lymph node | II | + | − | − | − | − | − |
| 23 | Lymph node | II | + | − | − | − | + | − |
| 24 | Lymph node | II | + | − | − | Tonsil | + | − |
| 25 | Lymph node | II? | + | − | NT | − | + | − |
| 26 | Lymph node | II | + | − | − | Tonsil | − | − |
| 27 | Lymph node | II | + | + | − | − | − | − |
| 28 | Lymph node | II? | + | − | NT | Hypopharynx | − | − |
| 29 | Lymph node | II | + | − | − | − | − | − |
| 30 | Lymph node | II | + | − | − | − | − | − |
| 31 | Lymph node | II | + | − | − | Tonsil | − | − |
| 32 | Lymph node | II | + | − | − | − | − | −-150,-151 |
| 33 | Lymph node | II | + | − | − | Tonsil | − | −-151 |
| 34 | Lymph node | II | + | − | − | Pleura | + | − |
| 35 | Lymph node | II | + | − | − | − | + | BCL2 |
| 36 | Lymph node | II | + | − | − | − | − | BCL2-151 |
| 37 | Lymph node | II | + | − | − | Tonsil | − | BCL2-151 |
| 38 | Lymph node | II | + | − | − | − | − | BCL2-151 |
| 39 | Lymph node | II | + | − | − | Tonsil | + | BCL2 |
| 40 | Lymph node | II | + | − | − | − | + | BCL2 |
| 41 | Lymph node | II | + | − | − | Tonsil | − | BCL2-151 |
| 42 | Lymph node | II | + | − | − | − | + | BCL2-151 |
| 43 | Lymph node | II | + | − | − | − | − | BCL2/BCL6 |
| 44 | Lymph node | II? | + | − | NT | − | − | BCL6 |
| 45 | Lymph node | II | + | + | − | − | − | BCL6 |
| 46 | Lymph node | II | + | − | − | Tongue | − | BCL6 |
| 47 | Lymph node | II | + | − | − | − | + | BCL6 |
| 48 | Lymph node | II | + | − | − | Tonsil | − | BCL6 |
| 49 | Lymph node | III | +/+ | − | − | − | − | − |
| 50 | Lymph node | III | +/+ | − | − | − | − | − |
| 51 | Lymph node | III | +/+ | − | − | Hypopharynx | + | − |
| 52 | Lymph node | III | +/+ | − | − | − | − | − |
| 53 | Lymph node | III | +/+ | − | − | − | − | −-151 |
| 54 | Lymph node | III | +/+ | − | − | Thyroid gland | − | −-151 |
| 55 | Lymph node | III | +/+ | − | − | − | − | − |
| 56 | Lymph node | III | +/+ | − | − | − | − | − |
| 57 | Lymph node | III | +/+ | − | − | − | − | − |
| 58 | Lymph node | III | +/+ | − | − | − | − | − |
| 59 | Lymph node | III | +/+ | − | − | Tonsil | + | − |
| 60 | Lymph node | III | +/+ | − | − | − | − | − |
| 61 | Lymph node | III? | +/+ | − | NT | Tonsil | + | − |
| 62 | Lymph node | III | +/+ | − | − | − | − | − |
| 63 | Lymph node | III? | +/+ | − | NT | − | + | BCL2 |
| 64 | Lymph node | III | +/+ | − | − | − | − | BCL2-151 |
| 65 | Lymph node | III | +/+ | − | − | Tonsil | + | BCL2/BCL6 |
| 66 | Lymph node | III | +/+ | − | − | − | − | BCL6 |
| 67 | Lymph node | III? | +/+ | − | NT | − | + | BCL6 |
| 68 | Lymph node | III? | +/+ | − | NT | − | − | BCL6 |
| 69 | Lymph node | III | +/+ | − | − | − | + | BCL6 |
| 70 | Lymph node | III | +/+ | − | − | − | − | BCL6 |
| 71 | Lymph node | III | +/+ | − | − | − | − | BCL6 |
| 72 | Lymph node | III | +/+ | − | − | − | − | BCL6/MYC |
| 73 | Lymph node | IV | + | + | + | − | − | − |
| 74 | Lymph node | IV | + | − | + | − | + | −-151 |
| 75 | Lymph node | IV | + | − | + | − | + | − |
| 76 | Lymph node | IV | + | − | − | Liver | + | − |
| 77 | Lymph node | IV | + | − | + | Tonsil | − | −-151 |
| 78 | Lymph node | IV | +/+ | + | + | Liver | − | −-151 |
| 79 | Lymph node | IV | + | − | + | − | + | −-151 |
| 80 | Lymph node | IV | + | − | + | − | + | − |
| 81 | Lymph node | IV | + | − | + | Tonsil | + | − |
| 82 | Lymph node | IV | + | − | + | − | − | −-151 |
| 83 | Lymph node | IV | +/+ | + | + | − | − | − |
| 84 | Lymph node | IV | +/+ | − | − | Liver | − | −-151 |
| 85 | Lymph node | IV | +/+ | + | + | − | + | − |
| 86 | Lymph node | IV | + | − | + | − | + | − |
| 87 | Spleen | IV | − | + | + | − | − | − |
| 88 | Lymph node | IV | +/+ | + | − | Pleura | + | BCL2 |
| 89 | Lymph node | IV | +/+ | − | + | − | + | BCL2-150 |
| 90 | Lymph node | IV | +/+ | + | + | − | + | BCL2 |
| 91 | Lymph node | IV | +/+ | − | + | − | − | BCL2-151 |
| 92 | Lymph node | IV | +/+ | + | + | − | + | BCL6 |
| 93 | Lymph node | IV | +/+ | − | + | − | − | BCL6 |
| Extranodal | ||||||||
| 94 | Bone | I | − | − | − | − | + | − |
| 95 | Bone | I | − | − | − | − | − | − |
| 96 | Skin | I | − | − | − | − | − | − |
| 97 | Stomach | I | − | − | − | − | − | −-151 |
| 98 | Stomach | I | − | − | − | − | + | −-151 |
| 99 | Soft tissue | I | − | − | − | − | − | −-151 |
| 100 | Ethmoid sinus | I | − | − | − | − | + | −-151 |
| 101 | Lacrimal gland | I | − | − | − | − | − | − |
| 102 | Submandibular gland | I | − | − | − | − | − | |
| 103 | Parotic gland | I | − | − | − | − | − | − |
| 104 | Thyroid gland | I? | − | − | NT | − | + | − |
| 105 | Testis | I? | − | − | NT | − | + | −-151 |
| 106 | Breast | I | − | − | − | − | − | − |
| 107 | Breast | I | − | − | − | − | + | − |
| 108 | Breast | I? | − | − | NT | − | + | BCL6 |
| 109 | Breast | I | − | − | − | − | + | BCL6 |
| 110 | Soft tissue | I | − | − | − | − | − | BCL6 |
| 111 | CNS | I | − | − | − | − | − | BCL6 |
| 112 | Stomach | I | − | − | − | − | − | BCL6 |
| 113 | Stomach | I | − | − | − | − | − | MYC-151 |
| 114 | Stomach | I | − | − | − | − | − | MYC-151 |
| 115 | Stomach | I | − | − | − | − | + | MYC-151 |
| 116 | Colon | II | + | − | − | − | + | − |
| 117 | Kidney | II | + | − | − | − | − | − |
| 118 | Appendix | II | + | − | − | − | − | −-151 |
| 119 | Small intestine | II | + | − | − | − | + | − |
| 120 | Thyroid gland | II | + | − | − | − | − | BCL2-151 |
| 121 | Colon | II | + | − | − | − | + | BCL2/BCL6 |
| 122 | Skin | II | + | − | − | − | − | BCL6 |
| 123 | Small intestine | II | + | − | − | − | + | BCL6 |
| 124 | Stomach | II | + | − | − | − | − | MYC-151 |
| 125 | Stomach | II? | + | − | NT | − | − | MYC-151 |
| 126 | Soft tissue | II | + | − | − | − | − | MYC-151 |
| 127 | Stomach | IV | + | − | − | Liver | − | −-151 |
| 128 | Stomach | IV | + | − | + | Esophagus | − | −-151 |
| 129 | Small intestine | IV | + | − | − | Peritoneum | − | − |
| 130 | Suprarenal gland | IV | + | − | − | Peritoneum | − | − |
| 131 | Colon | IV | − | − | + | − | − | − |
| 132 | Small intestine | IV | − | − | + | Sigmoid | + | − |
| 133 | Soft tissue | IV | − | − | − | Pleura | − | − |
| 134 | Liver | IV | + | − | NT | − | + | − |
| 135 | Testis | IV | + | − | + | − | + | −-151 |
| 136 | Bone | IV | − | − | + | − | + | BCL6 |
| 137 | CNS | IV | − | − | NT | Epidural | − | BCL6 |
| 138 | Lung | IV | − | − | + | Pleura | − | MYC-151 |
| Extensive | ||||||||
| 139 | Extensive | IV | + | − | + | CNS | − | −-151 |
| 140 | Extensive | IV | +/+ | − | + | Liver | + | − |
| 141 | Extensive | IV | + | − | + | Lung | − | − |
| 142 | Extensive | IV | +/+ | − | + | Pleura | + | − |
| 143 | Extensive | IV | +/+ | + | + | Liver | + | − |
| 144 | Extensive | IV | +/+ | − | − | Stomach, pleura | − | −-151 |
| peritoneum | ||||||||
| 145 | Extensive | IV | +/+ | + | − | Pleura, peritoneum | − | BCL2 |
| 146 | Extensive | IV | + | − | − | Breast | + | BCL2-151 |
| 147 | Extensive | IV | +/+ | + | + | Soft tissue | + | BCL2-151 |
| 148 | Extensive | IV | +/+ | − | − | Small intestine, parotic gland, pleura | + | BCL2-150 |
| 149 | Extensive | IV | +/+ | − | NT | CNS, liver | − | BCL2-151 |
| 150 | Extensive | IV | + | − | − | Liver, soft tissue | − | BCL2 |
| 151 | Extensive | IV | +/+ | − | − | Breast | − | BCL2 |
| 152 | Extensive | IV | +/+ | − | − | CNS, soft tissue | − | BCL6 |
| 153 | Extensive | IV | + | + | − | Kidney, pleura | + | BCL6 |
| 154 | Extensive | IV | +/+ | − | NT | Lung, pleura | − | BCL6 |
| 155 | Extensive | IV | +/+ | − | − | Small intestine | − | BCL6 |
| 156 | Extensive | IV | +/+ | − | + | Testis, lung, pleura | + | BCL6/MYC |