Mutated Oncogenes, Tumor-Suppressor Gene Products, Overexpressed Oncogene-Encoded Proteins, and Tissue-Specific Differentiation Proteins That Might be Candidates to Induce T-Cell Immunity in Malignant Diseases Treated With Autologous Transplantation
| Protein Target . | Genetic Abnormality . | Malignant Disease . | Frequency (%) . | Reference . |
|---|---|---|---|---|
| Hematologic malignancies | ||||
| Ig idiotype | — | NHL, CLL | 100 | Kwak, 1992187 |
| P210 bcr-abl | t(9;22)(q34;q11) | CML | 95 | Nowell and Hungerford, 1960188 |
| P815 bcr-abl | t(9,;22)(q34;q11) | ALL | 10-15 | Clark et al, 1987189 Kurzrock, 1987190 |
| PML-RARα | t(15;17)(q22;q11) | PML | 90 | de Thé et al, 1990191 |
| IgVH-bcl-2 | t(14;18) | Follicular NHL | 95 | Tsujimoto et al, 1984192 |
| N-Ras | Mutation | AML | 25 | Bos et al, 1987193 |
| P53 | Mutation | NHL | 15-30 | Imamura et al, 1994194 |
| Proteinase 3 | Overexpressed | CML | Dengler et al, 1995195 | |
| Solid tumors | ||||
| Epidermal growth factor | Overexpression | Breast cancer | 30-40 | Sainsbury et al, 1987196 Ro et al, 1988197 |
| Erb B2 (Her-2/neu) | Overexpression | Breast cancer Ovarian cancer | 15-25 20-30 | Slamon et al, 1987198 Slamon et al, 1989199 |
| Erb B3 | Overexpression | Breast cancer | 10-30 | Lemoine et al, 1992200 |
| Fibroblast growth factor | Overexpression | Breast cancer | 12 | Theillet et al, 1993201 |
| P53 | Mutation | Breast cancer | 30 | Saitoh et al, 1994202 Kovach et al, 1996203 |
| Epithelial cell mucin (MUC-1) | — | Breast cancer Ovarian cancer | 90 | Gendler et al, 1988204 Siddiqui et al, 1988205 |
| Carcino-embryonic antigen (CEA) | — | Breast cancer | 80 | Thompson et al, 1991206 |
| Protein Target . | Genetic Abnormality . | Malignant Disease . | Frequency (%) . | Reference . |
|---|---|---|---|---|
| Hematologic malignancies | ||||
| Ig idiotype | — | NHL, CLL | 100 | Kwak, 1992187 |
| P210 bcr-abl | t(9;22)(q34;q11) | CML | 95 | Nowell and Hungerford, 1960188 |
| P815 bcr-abl | t(9,;22)(q34;q11) | ALL | 10-15 | Clark et al, 1987189 Kurzrock, 1987190 |
| PML-RARα | t(15;17)(q22;q11) | PML | 90 | de Thé et al, 1990191 |
| IgVH-bcl-2 | t(14;18) | Follicular NHL | 95 | Tsujimoto et al, 1984192 |
| N-Ras | Mutation | AML | 25 | Bos et al, 1987193 |
| P53 | Mutation | NHL | 15-30 | Imamura et al, 1994194 |
| Proteinase 3 | Overexpressed | CML | Dengler et al, 1995195 | |
| Solid tumors | ||||
| Epidermal growth factor | Overexpression | Breast cancer | 30-40 | Sainsbury et al, 1987196 Ro et al, 1988197 |
| Erb B2 (Her-2/neu) | Overexpression | Breast cancer Ovarian cancer | 15-25 20-30 | Slamon et al, 1987198 Slamon et al, 1989199 |
| Erb B3 | Overexpression | Breast cancer | 10-30 | Lemoine et al, 1992200 |
| Fibroblast growth factor | Overexpression | Breast cancer | 12 | Theillet et al, 1993201 |
| P53 | Mutation | Breast cancer | 30 | Saitoh et al, 1994202 Kovach et al, 1996203 |
| Epithelial cell mucin (MUC-1) | — | Breast cancer Ovarian cancer | 90 | Gendler et al, 1988204 Siddiqui et al, 1988205 |
| Carcino-embryonic antigen (CEA) | — | Breast cancer | 80 | Thompson et al, 1991206 |