Patients at First Relapse Following Cladribine
| Number | 90 |
| Age | |
| Median (yr) | 52 |
| Range | 34-77 |
| Sex | |
| Male | 75 |
| Female | 15 |
| Disease duration before 2-CdA | |
| Median (mo) | 11 |
| Range | 0-233 |
| Treatment before 2-CdA | |
| None | 48 |
| Splenectomy alone | 10 |
| Interferon alone | 13 |
| Splenectomy, interferon | 12 |
| Splenectomy, interferon, 2′-deoxycoformycin | 2 |
| 2′-Deoxycoformycin alone | 1 |
| 2′-Deoxycoformycin, interferon | 1 |
| Other regimens | 3 |
| First response to 2-CdA | |
| Complete response | 76 |
| Partial response | 14 |
| Peripheral blood hematologic parameters at first relapse | |
| Absolute neutrophil count (×109/L) | |
| Median (range) | 2.1 (0.1-23.3) |
| Hemoglobin level (g/dL) | |
| Median (range) | 14.3 (4.8-17.5) |
| Platelet (×109/L) | |
| Median (range) | 163 (40-537) |
| Site of relapse | |
| Bone marrow | 78 |
| Peripheral blood | |
| Cytopenias alone | 3 |
| Circulating hairy cells alone | 7 |
| Cytopenias and circulating hairy cells | 1 |
| Splenomegaly and retroperitoneal lymphadenopathy | 1 |
| Duration to first relapse from 2-CdA therapy | |
| Median (months) | 29 |
| Range | 6-85 |
| Treatment at relapse | |
| None | 24 |
| 2-CdA | 63 |
| Splenectomy (later 2-CdA) | 2 |
| Interferon | 1 |
| Response to second course of 2-CdA (65 patients) | |
| Complete response | 33 |
| Partial response | 14 |
| No response | 6 |
| Unknown | 12 |
| Number | 90 |
| Age | |
| Median (yr) | 52 |
| Range | 34-77 |
| Sex | |
| Male | 75 |
| Female | 15 |
| Disease duration before 2-CdA | |
| Median (mo) | 11 |
| Range | 0-233 |
| Treatment before 2-CdA | |
| None | 48 |
| Splenectomy alone | 10 |
| Interferon alone | 13 |
| Splenectomy, interferon | 12 |
| Splenectomy, interferon, 2′-deoxycoformycin | 2 |
| 2′-Deoxycoformycin alone | 1 |
| 2′-Deoxycoformycin, interferon | 1 |
| Other regimens | 3 |
| First response to 2-CdA | |
| Complete response | 76 |
| Partial response | 14 |
| Peripheral blood hematologic parameters at first relapse | |
| Absolute neutrophil count (×109/L) | |
| Median (range) | 2.1 (0.1-23.3) |
| Hemoglobin level (g/dL) | |
| Median (range) | 14.3 (4.8-17.5) |
| Platelet (×109/L) | |
| Median (range) | 163 (40-537) |
| Site of relapse | |
| Bone marrow | 78 |
| Peripheral blood | |
| Cytopenias alone | 3 |
| Circulating hairy cells alone | 7 |
| Cytopenias and circulating hairy cells | 1 |
| Splenomegaly and retroperitoneal lymphadenopathy | 1 |
| Duration to first relapse from 2-CdA therapy | |
| Median (months) | 29 |
| Range | 6-85 |
| Treatment at relapse | |
| None | 24 |
| 2-CdA | 63 |
| Splenectomy (later 2-CdA) | 2 |
| Interferon | 1 |
| Response to second course of 2-CdA (65 patients) | |
| Complete response | 33 |
| Partial response | 14 |
| No response | 6 |
| Unknown | 12 |