p16INK4A/p15INK4B Deletions (in %) in ALL
| References . | p16 Ho . | p16 He . | p16 Mu . | p15 Del . | Comments . |
|---|---|---|---|---|---|
| Hebert et al109 and Cayuela et al110 | 45 | NA | NA | 36 | Adults and children Strong correlation of p16 and p15 deletion with T-cell ALL |
| Cayuela et al97 | 76 | 10 | 50 (2/4 He) | NA | Adults and children |
| Only T-cell samples analyzed | |||||
| Quesnel | 14 | NA | 1.1 (1/88) | NA | Mainly adults |
| et al113 | No association with T-cell ALL | ||||
| Associated with poor prognostic features | |||||
| 33% IFN-α gene deletion in p16-deleted cases | |||||
| Rasool et al114 | 27 | NA | 11 (1/9) | 4 | Children |
| 9 hemizygous deletions for 9q21 markers | |||||
| No association with T-cell ALL | |||||
| Haidar et al111 | 22 | 0 | NA | 11 | Adults |
| No association with T-cell ALL | |||||
| Ogawa et al112 | 27 | 16 | 0 | 34 | Mainly adults |
| p16 deletions more frequent in pre-B ALL | |||||
| All patients with loss of p15 also had loss of p16 | |||||
| IFN-α gene loss only with loss of p16 | |||||
| Dreyling et al115 | 45 | 45 | 0 | 45 | Only adult data presented, children omitted |
| Schröder et al118 | 17 | 10 | NA | NA | Adults and children |
| p16 deletions in 1/23 B-lineage and 6/7 T-cell ALL |
| References . | p16 Ho . | p16 He . | p16 Mu . | p15 Del . | Comments . |
|---|---|---|---|---|---|
| Hebert et al109 and Cayuela et al110 | 45 | NA | NA | 36 | Adults and children Strong correlation of p16 and p15 deletion with T-cell ALL |
| Cayuela et al97 | 76 | 10 | 50 (2/4 He) | NA | Adults and children |
| Only T-cell samples analyzed | |||||
| Quesnel | 14 | NA | 1.1 (1/88) | NA | Mainly adults |
| et al113 | No association with T-cell ALL | ||||
| Associated with poor prognostic features | |||||
| 33% IFN-α gene deletion in p16-deleted cases | |||||
| Rasool et al114 | 27 | NA | 11 (1/9) | 4 | Children |
| 9 hemizygous deletions for 9q21 markers | |||||
| No association with T-cell ALL | |||||
| Haidar et al111 | 22 | 0 | NA | 11 | Adults |
| No association with T-cell ALL | |||||
| Ogawa et al112 | 27 | 16 | 0 | 34 | Mainly adults |
| p16 deletions more frequent in pre-B ALL | |||||
| All patients with loss of p15 also had loss of p16 | |||||
| IFN-α gene loss only with loss of p16 | |||||
| Dreyling et al115 | 45 | 45 | 0 | 45 | Only adult data presented, children omitted |
| Schröder et al118 | 17 | 10 | NA | NA | Adults and children |
| p16 deletions in 1/23 B-lineage and 6/7 T-cell ALL |
Abbreviations: IFN-α, interferon-α; Ho, homozygous deletion; He, hemizygous deletion; Mu, point mutation; del, deletion; NA, not available.
Data analysis similar to Quesnel et al.108