Cytotoxicity of Recombinant Toxins Corrected for Binding Affinity
| Cell Line . | IC50 (pmol/L)/EC50 (nmol/L) . | |||
|---|---|---|---|---|
| . | GM-CSF–PE38KDEL . | DT388–GM-CSF . | Anti-TFR(Fv)–PE38KDEL . | DT388 – . |
| . | . | . | . | Anti-TFR(Fv) . |
| LS174T | 1 | 25 | 0.003 | 0.2 |
| SW403 | 0.4 | 5 | 0.007 | 0.35 |
| N87 | 0.2 | 1.3 | 0.001 | 0.1 |
| HTB-103 | 4 | 140 | 0.0007 | 0.1 |
| HL60 | >45 | 0.14 | 0.14 | 0.1 |
| TF-1 | 10 | 0.007 | 0.006 | 0.07 |
| U937 | 4 | 0.014 | 0.035 | 0.07 |
| Cell Line . | IC50 (pmol/L)/EC50 (nmol/L) . | |||
|---|---|---|---|---|
| . | GM-CSF–PE38KDEL . | DT388–GM-CSF . | Anti-TFR(Fv)–PE38KDEL . | DT388 – . |
| . | . | . | . | Anti-TFR(Fv) . |
| LS174T | 1 | 25 | 0.003 | 0.2 |
| SW403 | 0.4 | 5 | 0.007 | 0.35 |
| N87 | 0.2 | 1.3 | 0.001 | 0.1 |
| HTB-103 | 4 | 140 | 0.0007 | 0.1 |
| HL60 | >45 | 0.14 | 0.14 | 0.1 |
| TF-1 | 10 | 0.007 | 0.006 | 0.07 |
| U937 | 4 | 0.014 | 0.035 | 0.07 |
The IC50s shown in Tables 1 and 4 were converted to picomoles per liter and divided by the EC50 as shown in Fig 5.