Table 1. Diagnostic criteria for... | American Society of Hematology

Table 1.

Diagnostic criteria for epoetin-associated PRCA*

Criteria
Major criteria (each of the major criteria should be identified in all cases)
Treatment with epoetin for at least 3 weeks
Drop of hemoglobin level of about 1 g/L/day without transfusions or transfusion need of about 1 unit/week to keep hemoglobin level stable
Reticulocyte count less than 10 × 10⁹/L
No major drop of white blood cell or platelet counts
Minor features†
Skin and systemic allergic features
Confirmational investigations
Bone marrow aspirate with normal cellularity and less than 5% erythroblasts with evidence of maturation block‡
Serum assay shows presence of antierythropoietin antibodies and evidence of neutralizing ability

Criteria
Major criteria (each of the major criteria should be identified in all cases)
Treatment with epoetin for at least 3 weeks
Drop of hemoglobin level of about 1 g/L/day without transfusions or transfusion need of about 1 unit/week to keep hemoglobin level stable
Reticulocyte count less than 10 × 10⁹/L
No major drop of white blood cell or platelet counts
Minor features†
Skin and systemic allergic features
Confirmational investigations
Bone marrow aspirate with normal cellularity and less than 5% erythroblasts with evidence of maturation block‡
Serum assay shows presence of antierythropoietin antibodies and evidence of neutralizing ability

Casadevall et al.¹

Minor features provide suggestive evidence, which should be confirmed by bone marrow aspirate examination and serum assays for antibodies.

Although there is not international consensus, bone marrow biopsy should be considered to rule out lymphoproliferative disorders.