Table 4.

Genes predictive for early MDS by neighborhood analysis

Rank
Accession no.
Gene symbol
Definition
1   AA761181  CD24  CD24 antigen  
2  NM_006235 POU2AF1  POU domain, class 2, associating factor 1  
3   AK000168   —   —  
4  NM_007128 VPREB1  Pre-B lymphocyte gene 1  
5  NM_013378 VPREB3  Pre-B lymphocyte gene 3  
6  NM_000626 CD79B  CD79B antigen  
7   M11722  DNTT  Terminal deoxynucleotidyltransferase  
8   BF510692  PAX5  Paired box gene 5  
9   AF288571  LEF1  Lymphoid enhancer-binding factor 1  
10  NM_021813 BACH2  BTB and CNC homology 1  
11   A1084226  TOSO  Regulator of Fas-induced apoptosis  
12  NM_014879 GPR1105  G protein-coupled receptor 105  
13   AV699347   —  FLJ21545 fis, clone COL06195 
14   AA628440   —  FLJ21545 fis, clone COL06195 
15   AL136653  C10orf10  Chromosome 10 open reading frame 10  
16  NM_014863 GALNAC4S-6ST  B-cell RAG-associated protein  
17   AB050468  LRIG1  Leucine-rich repeats and Ig-like domains 1  
18  NM_018986 FLJ20356  Hypothetical protein FLJ20356 
19  NM_002003 FCN1  Ficolin 1  
20   AB003476  AKAP12  A kinase (PRKA) anchor protein (gravin) 12  
21  NM_030751 TCF8  Transcription factor 8  
22  NM_007287 MME  Membrane metalloendopeptidase (CD10)  
23   A1349506  C18orf1  Chromosome 18 open reading frame 1  
24   D13889  ID1  Inhibitor of DNA binding 1  
25  NM_013314 BLNK  B-cell linker  
26   X00452  HLA-DQA1  MHC, class II, DQ alpha 1  
27  NM_006887 ZFP36L2  Zinc finger protein 36, C3H type-like 2  
28   L01639  CXCR4  Chemokine (C-X-C motif) receptor 4  
29  NM_019058 RTP801  HIF-1 responsive RTP801  
30  NM_002341 LTB  Lymphotoxin beta  
31  NM_001442 FABP4  Fatty acid binding protein 4  
32   BF672975  LPL  Lipoprotein lipase  
33   M87789  IGHG3  Ig heavy chain constant gamma 3  
34   U88964  ISG20  Interferon-stimulated gene 20 kDa  
35   M16276  HLA-DQB1  MHC, class II, DQ beta 1  
36  NM_005904 MADH7  Mothers against decapentaplegic homolog 7  
37   AF348491  CXCR4  Chemokine (C-X-C motif) receptor 4  
38  NM_002201 ISG20  Interferon-stimulated gene 20 kDa  
39  NM_014747 RIMS3  Regulator of synaptic membrane exocytosis 3  
40  NM_004591 CCL20  Chemokine (C-C motif) ligand 20  
41   AK025348  KIAA1025  KIAA1025 protein  
42   AU147399  CAV1  Caveolin 1  
43  NM_004684 SPARCL1  SPARC-like 1  
44   L20966  PDE4B  cAMP-specific phosphodiesterase 4B  
45   BF725121  SKIL  SKI-like  
46   N30339  COL5A1  Collagen, type V, alpha 1  
47   AJ224869   —   —  
48  NM_020070 IGLL1  Ig lambda-like polypeptide 1  
49  NM_016459 PACAP  Proapoptotic caspase adaptor protein  
50  NM_000591 CD14  CD14 antigen  
51  NM_005346 HSPA1B  Heat shock 70 kDa protein 1B  
52   AF052094  EPAS1  Endothelial PAS domain protein 1  
53   AI962377  PPFIBP1  PTPRF interacting protein, binding protein 1  
54   AW276186  HLA-DQB1  MHC, class II, DQ beta 1  
55   BC001131  H1ST1H2BG  Histone 1, H2bg  
56   AW814026   —  FLJ21350 fis, clone COL02751 
57  NM_024070 STAG3  Stromal antigen 3  
58   S77154  NR4A2  Nuclear receptor 4A2  
59  NM_018371 ChGn  Chondroitin beta 1,4 N-acetylgalactosaminyltransferase  
60   X17115  IGHM  Ig heavy chain constant mu  
61  NM_001882 CRHBP  Corticotropin releasing hormone binding protein  
62   BE465032  C6orf62  Chromosome 6 orf 62  
63  NM_002135 NR4A1  Nuclear receptor 4A1  
64  NM_024914 MADH1  Mothers against decapentaplegic homolog 1  
65  NM_004199 P4HA2  Proline 4-hydroxylase, alpha polypeptide II  
66  NM_006169 NNMT  Nicotinamide N-methyltransferase  
67   BE973687  HES1  Hairy and enhancer of split 1  
68   BG495771  TCF4  Transcription factor 4  
69  NM_018292 QRSL1  Glutaminyl-tRNA synthase-like 1  
70   U54826  MADH1  Mothers against decapentaplegic homolog 1  
71  NM_002922 RGS1  Regulator of G-protein signaling 1  
72   M87790  IGL @  Ig lambda locus  
73   X89894  NR4A3  Nuclear receptor 4A3  
74   BG546884  CRIM1  Cysteine-rich motor neuron 1  
75   AL022324   —   IMAGE clone 5728597  
76  NM_001769 CD9  CD9 antigen (p24)  
77   AW117498  FOXO1A  Forkhead box O1A  
78  NM_002167 ID3  Inhibitor of DNA binding 3  
79  NM_006186 NR4A2  Nuclear receptor 4A2  
80   AL535380  BTG1  B-cell translocation gene 1  
81   D86983  D2S448  Melanoma-associated gene  
82  NM_018678 C14orf43  Chromosome 14 orf 43  
83  NM_005261 GEM  GTP binding protein overexpressed in skeletal muscle  
84  NM_000237 LPL  Lipoprotein lipase  
85   BF433429  TCF4  Transcription factor 4  
86  NM_001261 CDK9  Cyclin-dependent kinase 9 (CDC2-related kinase)  
87   AF077048  SSBP2  Single-stranded DNA binding protein 2  
88  NM_001731 BTG1  B-cell translocation gene 1  
89
 		NM_004338
 		C18orf1
 		 Chromosome 18 orf 1
 
Rank
Accession no.
Gene symbol
Definition
1   AA761181  CD24  CD24 antigen  
2  NM_006235 POU2AF1  POU domain, class 2, associating factor 1  
3   AK000168   —   —  
4  NM_007128 VPREB1  Pre-B lymphocyte gene 1  
5  NM_013378 VPREB3  Pre-B lymphocyte gene 3  
6  NM_000626 CD79B  CD79B antigen  
7   M11722  DNTT  Terminal deoxynucleotidyltransferase  
8   BF510692  PAX5  Paired box gene 5  
9   AF288571  LEF1  Lymphoid enhancer-binding factor 1  
10  NM_021813 BACH2  BTB and CNC homology 1  
11   A1084226  TOSO  Regulator of Fas-induced apoptosis  
12  NM_014879 GPR1105  G protein-coupled receptor 105  
13   AV699347   —  FLJ21545 fis, clone COL06195 
14   AA628440   —  FLJ21545 fis, clone COL06195 
15   AL136653  C10orf10  Chromosome 10 open reading frame 10  
16  NM_014863 GALNAC4S-6ST  B-cell RAG-associated protein  
17   AB050468  LRIG1  Leucine-rich repeats and Ig-like domains 1  
18  NM_018986 FLJ20356  Hypothetical protein FLJ20356 
19  NM_002003 FCN1  Ficolin 1  
20   AB003476  AKAP12  A kinase (PRKA) anchor protein (gravin) 12  
21  NM_030751 TCF8  Transcription factor 8  
22  NM_007287 MME  Membrane metalloendopeptidase (CD10)  
23   A1349506  C18orf1  Chromosome 18 open reading frame 1  
24   D13889  ID1  Inhibitor of DNA binding 1  
25  NM_013314 BLNK  B-cell linker  
26   X00452  HLA-DQA1  MHC, class II, DQ alpha 1  
27  NM_006887 ZFP36L2  Zinc finger protein 36, C3H type-like 2  
28   L01639  CXCR4  Chemokine (C-X-C motif) receptor 4  
29  NM_019058 RTP801  HIF-1 responsive RTP801  
30  NM_002341 LTB  Lymphotoxin beta  
31  NM_001442 FABP4  Fatty acid binding protein 4  
32   BF672975  LPL  Lipoprotein lipase  
33   M87789  IGHG3  Ig heavy chain constant gamma 3  
34   U88964  ISG20  Interferon-stimulated gene 20 kDa  
35   M16276  HLA-DQB1  MHC, class II, DQ beta 1  
36  NM_005904 MADH7  Mothers against decapentaplegic homolog 7  
37   AF348491  CXCR4  Chemokine (C-X-C motif) receptor 4  
38  NM_002201 ISG20  Interferon-stimulated gene 20 kDa  
39  NM_014747 RIMS3  Regulator of synaptic membrane exocytosis 3  
40  NM_004591 CCL20  Chemokine (C-C motif) ligand 20  
41   AK025348  KIAA1025  KIAA1025 protein  
42   AU147399  CAV1  Caveolin 1  
43  NM_004684 SPARCL1  SPARC-like 1  
44   L20966  PDE4B  cAMP-specific phosphodiesterase 4B  
45   BF725121  SKIL  SKI-like  
46   N30339  COL5A1  Collagen, type V, alpha 1  
47   AJ224869   —   —  
48  NM_020070 IGLL1  Ig lambda-like polypeptide 1  
49  NM_016459 PACAP  Proapoptotic caspase adaptor protein  
50  NM_000591 CD14  CD14 antigen  
51  NM_005346 HSPA1B  Heat shock 70 kDa protein 1B  
52   AF052094  EPAS1  Endothelial PAS domain protein 1  
53   AI962377  PPFIBP1  PTPRF interacting protein, binding protein 1  
54   AW276186  HLA-DQB1  MHC, class II, DQ beta 1  
55   BC001131  H1ST1H2BG  Histone 1, H2bg  
56   AW814026   —  FLJ21350 fis, clone COL02751 
57  NM_024070 STAG3  Stromal antigen 3  
58   S77154  NR4A2  Nuclear receptor 4A2  
59  NM_018371 ChGn  Chondroitin beta 1,4 N-acetylgalactosaminyltransferase  
60   X17115  IGHM  Ig heavy chain constant mu  
61  NM_001882 CRHBP  Corticotropin releasing hormone binding protein  
62   BE465032  C6orf62  Chromosome 6 orf 62  
63  NM_002135 NR4A1  Nuclear receptor 4A1  
64  NM_024914 MADH1  Mothers against decapentaplegic homolog 1  
65  NM_004199 P4HA2  Proline 4-hydroxylase, alpha polypeptide II  
66  NM_006169 NNMT  Nicotinamide N-methyltransferase  
67   BE973687  HES1  Hairy and enhancer of split 1  
68   BG495771  TCF4  Transcription factor 4  
69  NM_018292 QRSL1  Glutaminyl-tRNA synthase-like 1  
70   U54826  MADH1  Mothers against decapentaplegic homolog 1  
71  NM_002922 RGS1  Regulator of G-protein signaling 1  
72   M87790  IGL @  Ig lambda locus  
73   X89894  NR4A3  Nuclear receptor 4A3  
74   BG546884  CRIM1  Cysteine-rich motor neuron 1  
75   AL022324   —   IMAGE clone 5728597  
76  NM_001769 CD9  CD9 antigen (p24)  
77   AW117498  FOXO1A  Forkhead box O1A  
78  NM_002167 ID3  Inhibitor of DNA binding 3  
79  NM_006186 NR4A2  Nuclear receptor 4A2  
80   AL535380  BTG1  B-cell translocation gene 1  
81   D86983  D2S448  Melanoma-associated gene  
82  NM_018678 C14orf43  Chromosome 14 orf 43  
83  NM_005261 GEM  GTP binding protein overexpressed in skeletal muscle  
84  NM_000237 LPL  Lipoprotein lipase  
85   BF433429  TCF4  Transcription factor 4  
86  NM_001261 CDK9  Cyclin-dependent kinase 9 (CDC2-related kinase)  
87   AF077048  SSBP2  Single-stranded DNA binding protein 2  
88  NM_001731 BTG1  B-cell translocation gene 1  
89
 		NM_004338
 		C18orf1
 		 Chromosome 18 orf 1
 

Eighty-nine probe sets (corresponding to 80 genes) derived from neighborhood analysis are shown in rank order of prediction.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal