Analysis 3: Thrombocytopenia outcome
Study or subcategory . | LMWH, n/N . | UFH, n/N . | Weight, % . | OR random (95% CI) . |
|---|---|---|---|---|
| Onarheim et al,24 1986 | 0/25 | 0/27 | NE | NE |
| Helimann et al,23 1989 | 0/150 | 0/150 | NE | NE |
| Leyvraz et al,11 1991 | 0/174 | 2/175 | 4.71 | 0.20 (0.01, 4.17) |
| van de Loo et al,21 1992 | 0/167 | 0/168 | NE | NE |
| Prestar,22 1992 | 0/68 | 0/66 | NE | NE |
| Colwell et al,20 1994 | 10/398 | 5/207 | 12.96 | 1.04 (0.35, 3.09) |
| Forette and Wolmark,19 1995 | 0/146 | 1/149 | 4.36 | 0.34 (0.01, 8.36) |
| Nurmohamed et al,18 1995 | 11/718 | 20/709 | 15.01 | 0.54 (0.25, 1.13) |
| Warkentin et al,3 1995 | 96/333 | 100/332 | 16.88 | 0.94 (0.67, 1.31) |
| Ganzer et al,13 1999 | 0/325 | 10/307 | 5.20 | 0.04 (0.00, 0.75) |
| Pouplard et al,14 1999 | 26/171 | 89/157 | 16.14 | 0.14 (0.08, 0.23) |
| McLeod et al,17 2001 | 6/674 | 6/675 | 12.66 | 1.00 (0.32, 3.12) |
| Hillbom et al,16 2002 | 0/106 | 0/106 | NE | NE |
| Mahlfeld et al,12 2002 | 1/252 | 5/252 | 7.41 | 5.00 (0.2, 1.70) |
| Macdonald et al,15 2003 | 2/51 | 0/49 | 4.67 | 5.00 (0.23, 106.83) |
| Total (95% CI) | 3758 | 3529 | 100.00 | 0.47 (0.22, 1.02) |
Study or subcategory . | LMWH, n/N . | UFH, n/N . | Weight, % . | OR random (95% CI) . |
|---|---|---|---|---|
| Onarheim et al,24 1986 | 0/25 | 0/27 | NE | NE |
| Helimann et al,23 1989 | 0/150 | 0/150 | NE | NE |
| Leyvraz et al,11 1991 | 0/174 | 2/175 | 4.71 | 0.20 (0.01, 4.17) |
| van de Loo et al,21 1992 | 0/167 | 0/168 | NE | NE |
| Prestar,22 1992 | 0/68 | 0/66 | NE | NE |
| Colwell et al,20 1994 | 10/398 | 5/207 | 12.96 | 1.04 (0.35, 3.09) |
| Forette and Wolmark,19 1995 | 0/146 | 1/149 | 4.36 | 0.34 (0.01, 8.36) |
| Nurmohamed et al,18 1995 | 11/718 | 20/709 | 15.01 | 0.54 (0.25, 1.13) |
| Warkentin et al,3 1995 | 96/333 | 100/332 | 16.88 | 0.94 (0.67, 1.31) |
| Ganzer et al,13 1999 | 0/325 | 10/307 | 5.20 | 0.04 (0.00, 0.75) |
| Pouplard et al,14 1999 | 26/171 | 89/157 | 16.14 | 0.14 (0.08, 0.23) |
| McLeod et al,17 2001 | 6/674 | 6/675 | 12.66 | 1.00 (0.32, 3.12) |
| Hillbom et al,16 2002 | 0/106 | 0/106 | NE | NE |
| Mahlfeld et al,12 2002 | 1/252 | 5/252 | 7.41 | 5.00 (0.2, 1.70) |
| Macdonald et al,15 2003 | 2/51 | 0/49 | 4.67 | 5.00 (0.23, 106.83) |
| Total (95% CI) | 3758 | 3529 | 100.00 | 0.47 (0.22, 1.02) |
Total events for LMWH = 152; total events for UFH = 238. Test for heterogeneity: χ2 = 46.11; df = 9 (P < .001); I2 = 80.5%.
Test for overall effect: Z = 1.90 (P = .06).
NE indicates not estimable.