Analysis 2: HIT outcome (studies from categories A and B)
Study or subcategory . | Treatment-LMWH, n/N . | Control-UFH, n/N . | Weight, % . | OR random (95% CI) . |
|---|---|---|---|---|
| Leyvraz et al,11 1991 | 0/174 | 2/175 | 15.64 | 0.20 (0.01, 4.17) |
| Warkentin et al,3 1995 | 0/333 | 8/332 | 17.76 | 0.06 (0.00, 1.00) |
| Ganzer et al,13 1999 | 0/325 | 10/307 | 17.95 | 0.04 (0.00, 0.75) |
| Pouplard et al,14 1999 | 0/171 | 6/157 | 17.41 | 0.07 (0.00, 1.22) |
| Mahlfeld et al,12 2002 | 1/252 | 5/252 | 31.23 | 0.20 (0.02, 1.70) |
| Total (95% CI) | 1255 | 1223 | 100.00 | 0.10 (0.03, 0.33) |
Study or subcategory . | Treatment-LMWH, n/N . | Control-UFH, n/N . | Weight, % . | OR random (95% CI) . |
|---|---|---|---|---|
| Leyvraz et al,11 1991 | 0/174 | 2/175 | 15.64 | 0.20 (0.01, 4.17) |
| Warkentin et al,3 1995 | 0/333 | 8/332 | 17.76 | 0.06 (0.00, 1.00) |
| Ganzer et al,13 1999 | 0/325 | 10/307 | 17.95 | 0.04 (0.00, 0.75) |
| Pouplard et al,14 1999 | 0/171 | 6/157 | 17.41 | 0.07 (0.00, 1.22) |
| Mahlfeld et al,12 2002 | 1/252 | 5/252 | 31.23 | 0.20 (0.02, 1.70) |
| Total (95% CI) | 1255 | 1223 | 100.00 | 0.10 (0.03, 0.33) |
Review: JLEE meta (version 01); comparison: 02 UFH versus LMWH; outcome: 02 HIT (RCT and prospective studies).
Total events for treatment-LMWH = 1; for control-UFH = 31. Test for heterogeneity: χ2 = 1.18, df = 4 (P = .88), I2 = 0%.
Test for overall effect: Z = 3/74 (P < .001).