Data extracted from included studies
Study (study type and context of prophylaxis) and prophylaxis type . | Mean duration, d . | No. patients . | HIT outcome . | Thrombocytopenia outcome . |
|---|---|---|---|---|
| Warkentin et al3 (RCT, orthopedic surgery)* | ||||
| UFH | 10 | 332 | 8 | 100§ |
| Enoxaparin | 10 | 333 | 0 | 96§ |
| Leyvraz et al11 (RCT, orthopedic surgery)* | ||||
| UFH | 9-11 | 175 | 2 | 2 |
| Fraxiparin | 9-11 | 174 | 0 | 0 |
| Mahlfeld et al12 (prospective, orthopedic surgery)† | ||||
| UFH | 9 | 252 | 5 | NA |
| Enoxaparin | 9 | 252 | 1 | NA |
| Ganzer et al13 (prospective, orthopedic surgery)† | ||||
| UFH | NA | 307 | 10 | 89§ |
| Enoxaparin | NA | 325 | 0 | 26§ |
| Pouplard et al14 (prospective, cardiac surgery)† | ||||
| UFH | 10 | 157 | 6 | 0 |
| Dalteparin | 30 | 171 | 0 | 2 |
| Macdonald et al15 (RCT, cranial surgery)‡ | ||||
| UFH | 7 | 49 | NA | 0 |
| Dalteparin | 7 | 51 | NA | 0 |
| Hillbom et al16 (RCT, ischemic stroke)‡ | ||||
| UFH | 10 | 106 | NA | 6 |
| Enoxaparin | 10 | 106 | NA | 6 |
| McLeod et al17 (RCT, colorectal surgery)‡ | ||||
| UFH | 10 | 675 | NA | 20§ |
| Enoxaparin | 10 | 674 | NA | 11§ |
| Nurmohamed et al18 (RCT, general surgery)‡ | ||||
| UFH | 10 | 709 | NA | 1 |
| Enoxaparin | 10 | 718 | NA | 0 |
| Forette and Wolmark19 (RCT, hospitalized elderly)‡ | ||||
| UFH | 28 | 149 | NA | 5 |
| Nadroparin | 28 | 146 | NA | 10 |
| Colwell et al20 (RCT, orthopedic surgery)‡ | ||||
| UFH | 7 | 207 | NA | 0 |
| Enoxaparin | 7 | 398 | NA | 0 |
| Van de Loo et al21 (RCT, orthopedic surgery)‡ | ||||
| UFH | 14 | 168 | NA | 0 |
| Fraxiparin | 14 | 167 | NA | 0 |
| Prestar22 (RCT, lumbar surgery)‡ | ||||
| UFH | 6 | 66 | NA | 0 |
| Certoparin | 6 | 68 | NA | 0 |
| Heilmann et al23 (RCT, gynecologic surgery)‡ | ||||
| UFH | 6 | 150 | NA | 0 |
| Certoparin | 6 | 150 | NA | 0 |
| Onarheim et al24 (RCT, abdominal surgery)‡ | ||||
| UFH | 7 | 27 | NA | 0 |
| Dalteparin | 7 | 25 | NA | 0 |
Study (study type and context of prophylaxis) and prophylaxis type . | Mean duration, d . | No. patients . | HIT outcome . | Thrombocytopenia outcome . |
|---|---|---|---|---|
| Warkentin et al3 (RCT, orthopedic surgery)* | ||||
| UFH | 10 | 332 | 8 | 100§ |
| Enoxaparin | 10 | 333 | 0 | 96§ |
| Leyvraz et al11 (RCT, orthopedic surgery)* | ||||
| UFH | 9-11 | 175 | 2 | 2 |
| Fraxiparin | 9-11 | 174 | 0 | 0 |
| Mahlfeld et al12 (prospective, orthopedic surgery)† | ||||
| UFH | 9 | 252 | 5 | NA |
| Enoxaparin | 9 | 252 | 1 | NA |
| Ganzer et al13 (prospective, orthopedic surgery)† | ||||
| UFH | NA | 307 | 10 | 89§ |
| Enoxaparin | NA | 325 | 0 | 26§ |
| Pouplard et al14 (prospective, cardiac surgery)† | ||||
| UFH | 10 | 157 | 6 | 0 |
| Dalteparin | 30 | 171 | 0 | 2 |
| Macdonald et al15 (RCT, cranial surgery)‡ | ||||
| UFH | 7 | 49 | NA | 0 |
| Dalteparin | 7 | 51 | NA | 0 |
| Hillbom et al16 (RCT, ischemic stroke)‡ | ||||
| UFH | 10 | 106 | NA | 6 |
| Enoxaparin | 10 | 106 | NA | 6 |
| McLeod et al17 (RCT, colorectal surgery)‡ | ||||
| UFH | 10 | 675 | NA | 20§ |
| Enoxaparin | 10 | 674 | NA | 11§ |
| Nurmohamed et al18 (RCT, general surgery)‡ | ||||
| UFH | 10 | 709 | NA | 1 |
| Enoxaparin | 10 | 718 | NA | 0 |
| Forette and Wolmark19 (RCT, hospitalized elderly)‡ | ||||
| UFH | 28 | 149 | NA | 5 |
| Nadroparin | 28 | 146 | NA | 10 |
| Colwell et al20 (RCT, orthopedic surgery)‡ | ||||
| UFH | 7 | 207 | NA | 0 |
| Enoxaparin | 7 | 398 | NA | 0 |
| Van de Loo et al21 (RCT, orthopedic surgery)‡ | ||||
| UFH | 14 | 168 | NA | 0 |
| Fraxiparin | 14 | 167 | NA | 0 |
| Prestar22 (RCT, lumbar surgery)‡ | ||||
| UFH | 6 | 66 | NA | 0 |
| Certoparin | 6 | 68 | NA | 0 |
| Heilmann et al23 (RCT, gynecologic surgery)‡ | ||||
| UFH | 6 | 150 | NA | 0 |
| Certoparin | 6 | 150 | NA | 0 |
| Onarheim et al24 (RCT, abdominal surgery)‡ | ||||
| UFH | 7 | 27 | NA | 0 |
| Dalteparin | 7 | 25 | NA | 0 |