Parameters of the stochastic model
| . | Parameters . |
|---|---|
| R0 | Initial number of cells in reserve compartment (initial number of HSCs, compartment 1 cells) |
| C0 | Initial number of cells in contributing compartment (initial number of differentiating clones, compartment 2 cells) |
| K_R | Upper limit for numbers of HSCs in the HSC reserve |
| λ | HSC replication (self-renewal) rate |
| α | HSC apoptosis (death) rate |
| ν | HSC differentiation rate (average rate at which an HSC gives rise to a differentiating clone) |
| μ | Differentiating clone exhaustion rate (thus, 1/μ is the average length of time a differentiating clone contributes to blood cell production) |
| . | Parameters . |
|---|---|
| R0 | Initial number of cells in reserve compartment (initial number of HSCs, compartment 1 cells) |
| C0 | Initial number of cells in contributing compartment (initial number of differentiating clones, compartment 2 cells) |
| K_R | Upper limit for numbers of HSCs in the HSC reserve |
| λ | HSC replication (self-renewal) rate |
| α | HSC apoptosis (death) rate |
| ν | HSC differentiation rate (average rate at which an HSC gives rise to a differentiating clone) |
| μ | Differentiating clone exhaustion rate (thus, 1/μ is the average length of time a differentiating clone contributes to blood cell production) |
Note that each parameter can be individually set for population a cells vs population b cells, allowing for stochastic competition between the cell types.