Table 1. Cox regression analysis of... | American Society of Hematology

Table 1.

Cox regression analysis of influence of baseline factors on OS

	n	Univariate			Multivariate
	n	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P
Year of diagnosis, per y	6994	0.988	0.984-0.993	<.001	0.991	0.987-0.996	<.001
Age, per y	6993	1.052	1.050-1.054	<.001	1.045	1.042-1.047	<.001
Sex
Female	3370	1			1
Male	3624	1.025	0.975-1.079	.335	1.067	1.013-1.124	.015
AML type
De novo	4833	1			1
tAML	685	1.564	1.438-1.702	<.001	1.535	1.409-1.673	<.001
MDS/AML	902	1.741	1.616-1.876	<.001	1.474	1.364-1.593	<.001
MPN/AML	368	2.218	1.988-2.474	<.001	1.935	1.730-2.165	<.001
ECOG/WHO PS
0	1270	1			1
1	2971	1.415	1.312-1.526	<.001	1.254	1-162-1.353	<.001
2	1238	2.405	2.204-2.624	<.001	1.826	1.670-1.996	<.001
3	837	4.355	3.957-4.793	<.001	2.989	2.707-3.301	<.001
4	437	6.590	5.869-7400	<.001	5.176	4.598-5.827	<.001

	n	Univariate			Multivariate
	n	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P
Year of diagnosis, per y	6994	0.988	0.984-0.993	<.001	0.991	0.987-0.996	<.001
Age, per y	6993	1.052	1.050-1.054	<.001	1.045	1.042-1.047	<.001
Sex
Female	3370	1			1
Male	3624	1.025	0.975-1.079	.335	1.067	1.013-1.124	.015
AML type
De novo	4833	1			1
tAML	685	1.564	1.438-1.702	<.001	1.535	1.409-1.673	<.001
MDS/AML	902	1.741	1.616-1.876	<.001	1.474	1.364-1.593	<.001
MPN/AML	368	2.218	1.988-2.474	<.001	1.935	1.730-2.165	<.001
ECOG/WHO PS
0	1270	1			1
1	2971	1.415	1.312-1.526	<.001	1.254	1-162-1.353	<.001
2	1238	2.405	2.204-2.624	<.001	1.826	1.670-1.996	<.001
3	837	4.355	3.957-4.793	<.001	2.989	2.707-3.301	<.001
4	437	6.590	5.869-7400	<.001	5.176	4.598-5.827	<.001

Multivariate analysis included parameters with a minimum of missing data (ie, those listed, but not cytogenetic data).

CI, confidence interval; MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasia; tAML, therapy-related AML.