Table 2. Examples of chemotherapy and... | American Society of Hematology

Table 2.

Examples of chemotherapy and antiviral interactions

Drug	Effect	Recommendation
Cobicistat	Strong CYP3A4 inhibitor that will increase chemotherapy toxicity	Avoid with chemotherapy such as doxorubicin or vinca alkaloids
Fluconazole	CYP3A4 inhibitor that will increase chemotherapy toxicity	Avoid before and during doxorubicin or vinca alkaloids therapy
Ritonavir	Strong CYP3A4 inhibitor that will increase chemotherapy toxicity	Avoid with chemotherapy such as doxorubicin or vinca alkaloids
Zidovudine	Myelosuppression	Contraindicated with chemotherapy

Drug	Effect	Recommendation
Cobicistat	Strong CYP3A4 inhibitor that will increase chemotherapy toxicity	Avoid with chemotherapy such as doxorubicin or vinca alkaloids
Fluconazole	CYP3A4 inhibitor that will increase chemotherapy toxicity	Avoid before and during doxorubicin or vinca alkaloids therapy
Ritonavir	Strong CYP3A4 inhibitor that will increase chemotherapy toxicity	Avoid with chemotherapy such as doxorubicin or vinca alkaloids
Zidovudine	Myelosuppression	Contraindicated with chemotherapy