Genes differentially expressed on 8 hours of prednisolone exposure in this study and previously reported in the literature
| Gene . | Up- or down-regulation . | Cell lines studied‡ . | References . | ||
|---|---|---|---|---|---|
| Child ALL* . | Lymphoid cell lines† . | Nonleukemic cell lines† . | |||
| ZFP36L2 | Up | Up | — | 697 | Yoshida et al11 |
| FKBP5 | Up | Up | — | 697, Jurkat, CEM | Obexer et al,9 Planey et al,10 Yoshida et al11 |
| LIMK2 | Up | Up | — | CEM | Medh et al,40 Webb et al45 |
| NFIL3 | Up | Up | — | CEM | Medh et al,40 Webb et al45 |
| ISG20 | Up | Up | — | 697 | Yoshida et al11 |
| TXNIP | Up | Up | — | 697, CEM | Tonko et al,8 Planey et al,10 Medh et al,40 Webb et al45 |
| C18ORF1 | Up | Up | — | CEM | Tonko et al,8 Webb et al45 |
| BTEB1 | Up | Up | — | 697 | Planey et al10 |
| DUSP1 (MKP-1) | Up | Down§ | — | 697 | Planey et al10 |
| DSIP1 (GILZ) | Up | Up | — | 697, CEM | Tonko et al,8 Planey et al10 |
| BTG1 | Up | Up | — | WEHI7.2, S49.A2, CEM, 697 | Yoshida et al,11 Wang et al,12 Medh et al,40 Webb et al45 |
| ZBTB16 | Up | Up | — | CEM | Tonko et al8 |
| SNF1LK | Up | Up | — | 697 | Yoshida et al11 |
| TUBA1 | Up | Up | — | CEM | Medh et al,40 Webb et al45 |
| DUSP10 (MKP-5) | Up | Down | — | 697 | Planey et al10 |
| PGKI | Up | Down | — | CEM | Tonko et al8 |
| SGK | Up | Up | — | WEHI7.2, S49.A2 | Wang et al12 |
| PRG1 | Up | Up | — | CEM, 697 | Planey et al,10 Medh et al,40 Webb et al45 |
| EIF2C2 | Up | Down | — | CEM | Medh et al,39 Leong et al44 |
| PFKP | Up | Down | — | WEHI7.2, S49.A2 | Wang et al12 |
| BYSL | Down | Down | — | CEM | Tsai et al4 |
| SOCS1 | Up | Up | — | CEM, 697 | Tonko et al,8 Yoshida et al,11 Medh et al,40 Webb et al45 |
| MAP2K1 | Up | — | Up | Human bone marrow stromal cells (TM5) | Jeon et al46 |
| SDC2 | Up | — | Up | Human glomerular epithelial cells | Kasinath et al47 |
| CEBPD | Up | — | Up | Different rat and rabbit cell types | Ramji and Foka48 |
| GK | Up | — | Up | Rat adipocytes | Taylor et al49 |
| STAT1 | Down | — | Down | Human peripheral blood mononuclear cells | Hu et al50 |
| INSR | Up | — | Up | Human promonocytic cells | Leal et al51 |
| CYP1A1 | Down | — | Up | Human aorta endothelial cells | Celander et al52 |
| Gene . | Up- or down-regulation . | Cell lines studied‡ . | References . | ||
|---|---|---|---|---|---|
| Child ALL* . | Lymphoid cell lines† . | Nonleukemic cell lines† . | |||
| ZFP36L2 | Up | Up | — | 697 | Yoshida et al11 |
| FKBP5 | Up | Up | — | 697, Jurkat, CEM | Obexer et al,9 Planey et al,10 Yoshida et al11 |
| LIMK2 | Up | Up | — | CEM | Medh et al,40 Webb et al45 |
| NFIL3 | Up | Up | — | CEM | Medh et al,40 Webb et al45 |
| ISG20 | Up | Up | — | 697 | Yoshida et al11 |
| TXNIP | Up | Up | — | 697, CEM | Tonko et al,8 Planey et al,10 Medh et al,40 Webb et al45 |
| C18ORF1 | Up | Up | — | CEM | Tonko et al,8 Webb et al45 |
| BTEB1 | Up | Up | — | 697 | Planey et al10 |
| DUSP1 (MKP-1) | Up | Down§ | — | 697 | Planey et al10 |
| DSIP1 (GILZ) | Up | Up | — | 697, CEM | Tonko et al,8 Planey et al10 |
| BTG1 | Up | Up | — | WEHI7.2, S49.A2, CEM, 697 | Yoshida et al,11 Wang et al,12 Medh et al,40 Webb et al45 |
| ZBTB16 | Up | Up | — | CEM | Tonko et al8 |
| SNF1LK | Up | Up | — | 697 | Yoshida et al11 |
| TUBA1 | Up | Up | — | CEM | Medh et al,40 Webb et al45 |
| DUSP10 (MKP-5) | Up | Down | — | 697 | Planey et al10 |
| PGKI | Up | Down | — | CEM | Tonko et al8 |
| SGK | Up | Up | — | WEHI7.2, S49.A2 | Wang et al12 |
| PRG1 | Up | Up | — | CEM, 697 | Planey et al,10 Medh et al,40 Webb et al45 |
| EIF2C2 | Up | Down | — | CEM | Medh et al,39 Leong et al44 |
| PFKP | Up | Down | — | WEHI7.2, S49.A2 | Wang et al12 |
| BYSL | Down | Down | — | CEM | Tsai et al4 |
| SOCS1 | Up | Up | — | CEM, 697 | Tonko et al,8 Yoshida et al,11 Medh et al,40 Webb et al45 |
| MAP2K1 | Up | — | Up | Human bone marrow stromal cells (TM5) | Jeon et al46 |
| SDC2 | Up | — | Up | Human glomerular epithelial cells | Kasinath et al47 |
| CEBPD | Up | — | Up | Different rat and rabbit cell types | Ramji and Foka48 |
| GK | Up | — | Up | Rat adipocytes | Taylor et al49 |
| STAT1 | Down | — | Down | Human peripheral blood mononuclear cells | Hu et al50 |
| INSR | Up | — | Up | Human promonocytic cells | Leal et al51 |
| CYP1A1 | Down | — | Up | Human aorta endothelial cells | Celander et al52 |
— indicates not applicable.
From this study.
From the literature.
697 indicates human pre-B leukemia cell line; Jurkat, T-lineage leukemic cell line; CEM, T-lineage leukemic cell line; WEH17.2, T-cell lymphoma cell line; S49A2, T-cell lymphoma cell line.
Up-regulation reported in nonleukemic cell lines.53